DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b9

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_011248733.1	Gene:	Cyp2b9 / 13094	MGIID:	88600	Length:	517	Species:	Mus musculus

Alignment Length:	468	Identity:	140/468 - (29%)
Similarity:	238/468 - (50%)	Gaps:	55/468 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PVIGYLLFM---------GSEKHTRFM----------------ELAKQYGSLFSTRLGSQLTVVM 100
            |.:|:::.|         |:.:.|..:                .|.:::|.:|:..||.:..||:
Mouse    40 PGVGWIILMIAGLLRKVYGAVEQTMDVRGKQNALVIQHAPLDQRLQEKHGDVFTVHLGPRPVVVL 104

  Fly   101 SDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNG 162
            ...:.|||..  ..|.|:||......| .:..|||..::|:.||..|||....:::|||     |
Mouse   105 CGTQTIREALVDHAEAFSGRGTIAAAQLVMQDYGIFFASGQRWKTLRRFSLATMKEFGM-----G 164

  Fly   163 KQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF-------- 219
            |:.:::||..|....:..|....|.|:|.:.:.....:|:|||::...||...|.:|
Mouse   165 KRSVEERIKEEAQCLVEELKKYQGVPLDPTFLFQCITANIICSIVFGERFDYTDDQFLHLLNLMY 229

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNN 284
            :.|:.|.....::| |:    :...::.||.:   ..:|.:.:.|:..:....::.||.:.||:.
Mouse   230 KIFSLLSSFSGQMF-EL----FSGFLKYFPGV---HRQIVKKQQELLDYIAHSVEKHKATLDPSA 286

  Fly   285 IRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPK 349
            .||.:|.||..:||.|:.      .:.:.|.:.|:..::.||.||.||...||.:..:.||:.|.
Mouse   287 PRDYIDTYLLRMEKEKSN------HNTEFHHQNLMMSVLSLFFAGTETTSATLHYGVLLMLKYPH 345

  Fly   350 EMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPA 414
            ...:||.|:|||:|.|||||::|...:|.|::.|.|..|.|.:||:...|...:|....||.:|.
Mouse   346 VTEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDLVPIGLPHKVIKDTLFRGYLLPK 410

  Fly   415 GSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLF 479
            .:.|.|:::|...||..:|:|::|.|..|:|..|.::|.|.|:||..|:|:|||:.:||.|||:|
Mouse   411 NTEVYPVLSSALHDPQYFEQPDKFNPEHFLDANGALKKCEAFLPFSTGKRICLGESIARNELFIF 475

  Fly   480 FASFMHCFDIALP 492
            |.:.:..|.:|.|
Mouse   476 FTTILQNFSVASP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	140/468 (30%)
Cyp2b9	XP_011248733.1	p450	82..512	CDD:365848	135/426 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720