DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b13

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_006539571.1	Gene:	Cyp2b13 / 13089	MGIID:	88599	Length:	517	Species:	Mus musculus

Alignment Length:	503	Identity:	153/503 - (30%)
Similarity:	247/503 - (49%)	Gaps:	68/503 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PVIGYLLFM---------GSEKHTRFM----------------ELAKQYGSLFSTRLGSQLTVVM 100
            |.:|:::.|         |:.:.|..:                .|.:::|.:|:..||.:..||:
Mouse    40 PGVGWIILMIAGLLRKVYGAVEQTMDVRGKQNALVIQHAPLDQRLQEKHGDVFTVHLGPRPVVVL 104

  Fly   101 SDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNG 162
            ...:.|||..  ..|.|:||......| .:..|||..|:|:.||..|||....:::|||     |
Mouse   105 CGTQTIREALVNNAEAFSGRGTIAAAQLVMQDYGIFFSSGERWKTLRRFSLATMKEFGM-----G 164

  Fly   163 KQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIE 227
            |:.:::||..|....:..|....|.|:|.:.......:|:|||::...||...|.:|.|.
Mouse   165 KRSVEERIKEEAQCLVEELKKYQGAPLDPTFFFQCVTANIICSIVFGERFDYTDEQFLRL----- 224

  Fly   228 EGMRLFGEIHTVDYIPTMQC------------FPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
              :.|..:|:::  :.:..|            ||.:   ..:||:|:.|:..|....::.|:.:.
Mouse   225 --LNLMYQIYSL--LRSFSCQMFELFSGLLKYFPGV---HRQIAKNQQEILNFITHRVEKHRATL 282

  Fly   281 DPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFML 345
            ||:..||.:|.||..:||.|:.      .:.:.|.:.|:..::.||.||.||..|||....:.||
Mouse   283 DPSEPRDFIDTYLLRMEKEKSN------HNTEFHHQNLMMSVLSLFFAGTETTSTTLCCGFLLML 341

  Fly   346 RNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGY 410
            ..|....:||.|:|||:|.|||||::|...:|.|::.|.|..|.|.|||....|..|:|....||
Mouse   342 MYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDIVPTGAPHRVTKDTMFRGY 406

  Fly   411 TIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARME 475
            .:|..:.|.|:::|...||..:|:|:.|.|..|:|..|.::|.|.|:||..|:|:|||:.:||.|
Mouse   407 LLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNE 471

  Fly   476 LFLFFASFMHCFDIALPEGQ---PLPSLKGNVGATITPESFKVCLKRR 520
            |||||.|.:..|.:|.|...   .|...:..:|.  .|.::::|...|
Mouse   472 LFLFFTSILQNFSVASPVASKDIDLTPKESGIGK--IPPTYQICFLAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	151/498 (30%)
Cyp2b13	XP_006539571.1	p450	82..514	CDD:365848	146/456 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720