DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2b10

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_034129.1	Gene:	Cyp2b10 / 13088	MGIID:	88598	Length:	491	Species:	Mus musculus

Alignment Length:	509	Identity:	170/509 - (33%)
Similarity:	269/509 - (52%)	Gaps:	39/509 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VFLGLLALVTLLQWLVRNYRELR-KLPPGPWGLPVIGYLLFM---GSEKHTRFMELAKQYGSLFS 89
            |.|.|..||..|..|.|.:.:.| ..||||..||::|.||.|   |..|  .|::|.::||.:|:
Mouse     5 VLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLLQMDRGGLLK--SFIQLREKYGDVFT 67

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRFLHDKL 151
            ..||.:..|::.....|||..  :.|.|:||.....:: |...||:|.:.|:.||..|||....:
Mouse    68 VHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVAVVEPTFKEYGVIFANGERWKTLRRFSLATM 132

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |.|||     ||:.:::||..|....:..|..|.|.|:|.:.:.....:|:|||::...||...|
Mouse   133 RDFGM-----GKRSVEERIQEEAQCLVEELRKSQGAPLDPTFLFQCITANIICSIVFGERFEYTD 192

  Fly   217 PKFRRFNFLIEEGMRLFGEIHTVD------YIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDD 275
            .:|.|   |:|...:.|..|.:..      :...::.||.   |..:|::|..|:..:....::.
Mouse   193 RQFLR---LLELFYQTFSLISSFSSQMFELFSGFLKYFPG---AHRQISKNLQELLDYIGHSVEK 251

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAKA-EGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLW 339
            |:.:.||:..||.:|.||..:||.|: :.|:.       |.:.|:..::.||.||.||..|||.:
Mouse   252 HRATLDPSVPRDFIDIYLLRMEKEKSNQHTEF-------HHQNLMMSVLSLFFAGTETSSTTLRY 309

  Fly   340 INVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRD 404
            ..:.||:.|....:||.|:|||:|.|||||::|...:|.|::.|.|..|.|.::|:...|..|:|
Mouse   310 GFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKD 374

  Fly   405 VELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGD 469
            ....||.:|..:.|.|:::|...||..:|:|:.|.|..|:|..|.::|.|.|:||..|:|:|||:
Mouse   375 TMFRGYLLPKNTEVYPILSSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGE 439

  Fly   470 VLARMELFLFFASFMHCFDIA---LPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            .:||.||||||.|.:..|.:|   .|:...|...:..:|.  .|.::::|...|
Mouse   440 SIARNELFLFFTSILQNFSVASHVAPKDIDLTPKESGIGK--IPPTYQICFLAR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	159/478 (33%)
Cyp2b10	NP_034129.1	p450	42..488	CDD:278495	152/467 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720