DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2a5

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_031838.2	Gene:	Cyp2a5 / 13087	MGIID:	88597	Length:	494	Species:	Mus musculus

Alignment Length:	512	Identity:	164/512 - (32%)
Similarity:	267/512 - (52%)	Gaps:	59/512 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMV----FLGLLALVTLLQWLVRNYRELR-KLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQY 84
            ||:|    ||.:|.|:::  |   ..|:|. ||||||..||.||..|.:.:|: :...|:::::|
Mouse     6 LLLVAAVAFLSVLVLMSV--W---KQRKLSGKLPPGPTPLPFIGNFLQLNTEQMYNSLMKISQRY 65

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPD-TPFMQTLNGYGIINSTGKLWKDQRRF 146
            |.:|:..||.:..||:...:.::|..  :.|||:||.: ..|.....|||:..|:|:..|..|||
Mouse    66 GPVFTIYLGPRRIVVLCGQEAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSSGERAKQLRRF 130

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....||.||:     ||:.:::||..|....|.....::|..:|.:..:|..|||||.|::...|
Mouse   131 SIATLRDFGV-----GKRGIEERIQEEAGFLIDSFRKTNGAFIDPTFYLSRTVSNVISSIVFGDR 190

  Fly   212 FSIDDPKF--------RRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRF 268
            |..:|.:|        ..|.|....    .|:::.: :...|:..|.......|..|.   ::.|
Mouse   191 FDYEDKEFLSLLRMMLGSFQFTATS----MGQLYEM-FSSVMKHLPGPQQQAFKELQG---LEDF 247

  Fly   269 YQDVIDDHKRSFDPNNIRDLVDFYLCE-IEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMET 332
            ....::.::|:.|||:.||.:|.:|.. :|:.|...|:   |..||    ||...::||.||.||
Mouse   248 ITKKVEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTE---FYMKN----LVLTTLNLFFAGTET 305

  Fly   333 IKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLAT 397
            :.|||.:..:.::::|....:|.:|:|:|:||:|.|..||...:|.||:.|.|..|.:.::|:..
Mouse   306 VSTTLRYGFLLLMKHPDIEAKVHEEIDRVIGRNRQPKYEDRMKMPYTEAVIHEIQRFADMIPMGL 370

  Fly   398 THSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVG 462
            ....|:|.:...:.:|.|:.|.|::.||..||..:..|::|.|..|:|.:|:.:|.:.|:||.:|
Mouse   371 ARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKNDAFVPFSIG 435

  Fly   463 RRMCLGDVLARMELFLFFASFMHCF---------DIALPEGQPLPSLKGNVGATITP 510
            :|.|.|:.|||||||||..:.|..|         ||.:.     |.|.|  .|||.|
Mouse   436 KRYCFGEGLARMELFLFLTNIMQNFHFKSTQAPQDIDVS-----PRLVG--FATIPP 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	152/479 (32%)
Cyp2a5	NP_031838.2	p450	34..491	CDD:278495	152/479 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720