Protein Alignment Cyp18a1 and Cyp2a4

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034127.2
• Gene: Cyp2a4 / 13086
• MGIID: 88596
• Length: 494
• Species: Mus musculus
• Alignment Length: 503
• Identity: 163/503 - (32%)
• Similarity: 270/503 - (53%)
• Gaps: 41/503 - (8%)

  Fly    26 LLMV----FLGLLALVTLLQWLVRNYRELR-KLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQY 84
            ||:|    ||.:|.|:::  |   ..|:|. ||||||..||.:|..|.:.:|: :...|:::::|
Mouse     6 LLLVAAVAFLSVLVLMSV--W---KQRKLSGKLPPGPTPLPFVGNFLQLNTEQMYNSLMKISQRY 65

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPD-TPFMQTLNGYGIINSTGKLWKDQRRF 146
            |.:|:..|||:..||:...:.::|..  :.|||:||.: ..|.....||||..|:|:..|..|||
Mouse    66 GPVFTIYLGSRRIVVLCGQETVKEALVDQAEEFSGRGEQATFDWLFKGYGIAFSSGERAKQLRRF 130

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....||.||:     ||:.:::||..|....|.....::|..:|.:..:|..|||||.|::...|
Mouse   131 SITTLRDFGV-----GKRGIEERIQEEAGFLIDSFRKTNGAFIDPTFYLSRTVSNVISSIVFGDR 190

  Fly   212 FSIDDPKFRRFNFLIEEGMRL----FGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDV 272
            |..:|.:|.....::...::.    .|:::.: :...|:..|.......|..|.   ::.|....
Mouse   191 FDYEDKEFLSLLRMMLGSLQFTATSMGQVYEM-FSSVMKHLPGPQQQAFKELQG---LEDFITKK 251

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCE-IEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTT 336
            ::.::|:.|||:.||.:|.:|.. :|:.|...|:   |..||    ||...::||.||.||:.||
Mouse   252 VEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTE---FYMKN----LVLTTLNLFFAGTETVSTT 309

  Fly   337 LLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSP 401
            |.:..:.:::.|....:|.:|:|:|:||:|.|..||...:|.||:.|.|..|.:.::|:......
Mouse   310 LRYGFLLLMKYPDIEAKVHEEIDRVIGRNRQPKYEDRMKMPYTEAVIHEIQRFADLIPMGLARRV 374

  Fly   402 TRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMC 466
            |:|.:...:.:|.|:.|.|::.||..||..:..|::|.|..|:|.:|:.:|.:.|:||.:|:|.|
Mouse   375 TKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKSDAFVPFSIGKRYC 439

  Fly   467 LGDVLARMELFLFFASFMHCFDI-ALPEGQPL---PSLKGNVGATITP 510
            .|:.|||||||||..:.|..|.. :..|.|.:   |.|.|.|  ||.|
Mouse   440 FGEGLARMELFLFLTNIMQNFHFKSTQEPQDIDVSPRLVGFV--TIPP 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	140/438 (32%)
Cyp2a4	NP_034127.2	CYP2A	65..489	CDD:410761	141/439 (32%)