DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2a12

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_598418.1	Gene:	Cyp2a12 / 13085	MGIID:	105055	Length:	492	Species:	Mus musculus

Alignment Length:	498	Identity:	156/498 - (31%)
Similarity:	262/498 - (52%)	Gaps:	41/498 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYGSLFST 90
            ::.||.::.||::.|..:|.     ||||||..||.|| ||.....:.::...:|.:.||.:|:.
Mouse    11 ILAFLSVMVLVSVWQQKIRG-----KLPPGPIPLPFIGNYLQLNRKDVYSSITQLQEHYGPVFTI 70

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLR 152
            .||.:..||:..|..::|..  ..|||:||.:.....|| .|||:..|.|:..|..|||....||
Mouse    71 HLGPRRVVVLYGYDAVKEALVDHAEEFSGRGEQATFNTLFKGYGVAFSNGERAKQLRRFSIATLR 135

  Fly   153 QFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDP 217
            .|||     ||:.:::||..|....|..|..:.|.|:|.:..:|...||||.|::...||:.:|.
Mouse   136 DFGM-----GKRGVEERIQEEAGCLIKMLQGTCGAPIDPTIYLSKTASNVISSIVFGDRFNYEDK 195

  Fly   218 KFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTA-------KNKIAQNRAEMQRFYQDVIDD 275
            :|...       :::.|:::.....||.|.:....:.       :.:|.::..:::.|....:..
Mouse   196 EFLSL-------LQMMGQVNKFAASPTGQLYDMFHSVMKYLPGPQQQIIKDSHKLEDFMIQKVKQ 253

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWI 340
            ::.:.|||:.||.:|.:|..::|.|       ..:.:.|.:.||...::||.||.||:.:||.:.
Mouse   254 NQSTLDPNSPRDFIDSFLIHMQKEK-------YVNSEFHMKNLVMTSLNLFFAGSETVSSTLRYG 311

  Fly   341 NVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDV 405
            .:.::::|....:|.:|:|:|:||:|.|..||...:|.|::.|.|..|.|:..||......|:|.
Mouse   312 FLLLMKHPDVEAKVHEEIDRVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNFAPLGIPRRITKDT 376

  Fly   406 ELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDV 470
            ...|:.:|.|:.|.|::.|:..||..:..|::|.|..|:|.:|:::|...|:||..|:|.||||.
Mouse   377 SFRGFFLPKGTEVFPILGSLMTDPKFFSSPKDFNPQHFLDDKGQLKKIPAFLPFSTGKRFCLGDS 441

  Fly   471 LARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESF 513
            ||:|||||||.:.:..|....|.     .|: ::..:.|||.|
Mouse   442 LAKMELFLFFTTILQNFRFKFPR-----KLE-DINESPTPEGF 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	148/471 (31%)
Cyp2a12	NP_598418.1	p450	33..489	CDD:278495	148/471 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm43796
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720