Protein Alignment Cyp18a1 and Cyp21a1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034125.2
• Gene: Cyp21a1 / 13079
• MGIID: 88591
• Length: 487
• Species: Mus musculus
• Alignment Length: 522
• Identity: 153/522 - (29%)
• Similarity: 243/522 - (46%)
• Gaps: 67/522 - (12%)

  Fly    28 MVFLGLLALVTLL---QWLVRNYRELRK--LPP-GPWGLPVIGYLLFMGSEKHTRFMELAKQYGS 86
            |:..|||.|:.||   :||...:: |||  ||| .|      |:|.|:........:.|.::.|.
Mouse     1 MLLPGLLLLLLLLAGTRWLWGQWK-LRKLHLPPLAP------GFLHFLQPNLPIYLLGLTQKLGP 58

  Fly    87 LFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNGYGIIN-STGK---LWKDQRR 145
            ::..|||.|..||::..:.|.|...::  :|.|||     ..|||...:: |.|.   :||..::
Mouse    59 IYRIRLGMQDVVVLNSNRTIEEALIQKWVDFAGRP-----HMLNGKMDLDLSLGDYSLMWKAHKK 118

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMST 210
            .....| ..||      :..|:..|.....||...:.|..|.||.:....|....::|..|....
Mouse   119 LSRSAL-MLGM------RDSMEPLIEQLTQEFCERMRAQAGTPVAIHKEFSFLTCSIISCLTFGD 176

  Fly   211 RFSIDDPKFRRFNFLIEEGMRLFG--EIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVI 273
            :   |....:..:..:::.::.:.  .|..:..||.::..|  :....|:.|.:.......:..:
Mouse   177 K---DSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLRFLP--NPGLQKLKQIQESRDHIVKQQL 236

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            ..||.|......:|::|:.|..:||.: :|.|.|    :.||..:...::|||..|.||..|||.
Mouse   237 KRHKDSLVAGQWKDMIDYMLQGVEKQR-DGKDEE----RLHEGHVHMSVVDLFIGGTETTATTLS 296

  Fly   339 WINVFMLRNPKEMRRVQDELD-------QVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLA 396
            |...|:|.:|:..:|:|:|||       |::.|:|:       .||:..:||.|.:|...:||||
Mouse   297 WAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRM-------QLPLLMATIAEVLRLRPVVPLA 354

  Fly   397 TTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGV 461
            ..|..||...::||.||....:||.|...::|..:||.|.:|.|.||::.....|.|.    ||.
Mouse   355 LPHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWELPSKFWPDRFLEPGKNPRTPS----FGC 415

  Fly   462 GRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLK----GNVGATITPESFKVCLKRRPL 522
            |.|:|||:.|||:|||:..|..:..|.:..|....||||:    ..:...|.|  |:|.|:.|.|
Mouse   416 GARVCLGEPLARLELFVVLARLLQAFTLLPPPDGTLPSLQPQPYAGINLPIPP--FQVRLQPRNL 478

  Fly   523 GP 524
            .|
Mouse   479 AP 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	128/448 (29%)
Cyp21a1	NP_034125.2	CYP21	56..474	CDD:410767	129/452 (29%)