Protein Alignment Cyp18a1 and Cyp1b1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034124.1
• Gene: Cyp1b1 / 13078
• MGIID: 88590
• Length: 543
• Species: Mus musculus
• Alignment Length: 528
• Identity: 168/528 - (31%)
• Similarity: 258/528 - (48%)
• Gaps: 36/528 - (6%)

  Fly    12 LRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNY-RELRKLPPGPWGLPVIGYLLFMGSEKHT 75
            |..|..||.     .|::...:||.|.|.|||:|.: |:....||||:..|:||....:|...|.
Mouse    13 LSSLSTQQT-----TLLLLFSVLAAVHLGQWLLRQWQRKPWSSPPGPFPWPLIGNAAAVGQASHL 72

  Fly    76 RFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTLNGYGIINSTGK 138
            .|..||::||.:|..||||...||::....|.:...::.  |..||  ||.    .:.:::....
Mouse    73 YFARLARRYGDVFQIRLGSCPVVVLNGESAIHQALVQQGSIFADRP--PFA----SFRVVSGGRS 131

  Fly   139 L--------WKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL--HASDGQPVDMSP 193
            |        ||.|||..:..:|.|. |.....:..::...:.|..|.:..|  ..:.|..:|.:.
Mouse   132 LAFGHYSEHWKTQRRSAYSTMRAFS-TRHPRSRGLLEGHALAEARELVAVLVRRCAGGAFLDPTQ 195

  Fly   194 VISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNK 257
            .:.|||:||:.::....|::.||.:|.......||..|..|....||.:|.:|.||: :.|...|
Mouse   196 PVIVAVANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVLPWLQLFPNPVRTTFRK 260

  Fly   258 IAQNRAEMQRFYQDVIDDHKRSFDPNNI-RDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQV 321
            ..|.......|..|....|:.|..|... ||:.|.::...|| ||.|...:...|.:.|: :...
Mouse   261 FEQLNRNFSNFVLDKFLRHRESLVPGAAPRDMTDAFILSAEK-KASGAPGDDSSGLDLED-VPAT 323

  Fly   322 IIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILES 386
            |.|:|.|..:|:.|.|||:.:...|.|....|||.||||||||.|||.:.|...||...:.:.||
Mouse   324 ITDIFGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYES 388

  Fly   387 MRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEGK 449
            ||.||.:|:...|:.|.:..:.||.||  .:.:..:|  ||:.||..|..||:|.|:||:|.:|.
Mouse   389 MRFSSFLPVTIPHATTANTFVLGYYIP--KNTVVFVNQWSVNHDPAKWPNPEDFDPARFLDKDGF 451

  Fly   450 VRK--PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPES 512
            :.|  ....:.|.||:|.|:|:.|::|.||||.:...|..:....:.:. .::..:.|.||.|:|
Mouse   452 INKALASSVMIFSVGKRRCIGEELSKMLLFLFISILAHQCNFKANQNES-SNMSFSYGLTIKPKS 515

  Fly   513 FKVCLKRR 520
            |::.:..|
Mouse   516 FRIHVSLR 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	140/447 (31%)
Cyp1b1	NP_034124.1	CYP1B1-like	81..518	CDD:410768	141/448 (31%)