DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp1b1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_034124.1	Gene:	Cyp1b1 / 13078	MGIID:	88590	Length:	543	Species:	Mus musculus

Alignment Length:	528	Identity:	168/528 - (31%)
Similarity:	258/528 - (48%)	Gaps:	36/528 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNY-RELRKLPPGPWGLPVIGYLLFMGSEKHT 75
            |..|..||.     .|::...:||.|.|.|||:|.: |:....||||:..|:||....:|...|.
Mouse    13 LSSLSTQQT-----TLLLLFSVLAAVHLGQWLLRQWQRKPWSSPPGPFPWPLIGNAAAVGQASHL 72

  Fly    76 RFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTLNGYGIINSTGK 138
            .|..||::||.:|..||||...||::....|.:...::.  |..||  ||.    .:.:::....
Mouse    73 YFARLARRYGDVFQIRLGSCPVVVLNGESAIHQALVQQGSIFADRP--PFA----SFRVVSGGRS 131

  Fly   139 L--------WKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHL--HASDGQPVDMSP 193
            |        ||.|||..:..:|.|. |.....:..::...:.|..|.:..|  ..:.|..:|.:.
Mouse   132 LAFGHYSEHWKTQRRSAYSTMRAFS-TRHPRSRGLLEGHALAEARELVAVLVRRCAGGAFLDPTQ 195

  Fly   194 VISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNK 257
            .:.|||:||:.::....|::.||.:|.......||..|..|....||.:|.:|.||: :.|...|
Mouse   196 PVIVAVANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVLPWLQLFPNPVRTTFRK 260

  Fly   258 IAQNRAEMQRFYQDVIDDHKRSFDPNNI-RDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQV 321
            ..|.......|..|....|:.|..|... ||:.|.::...|| ||.|...:...|.:.|: :...
Mouse   261 FEQLNRNFSNFVLDKFLRHRESLVPGAAPRDMTDAFILSAEK-KASGAPGDDSSGLDLED-VPAT 323

  Fly   322 IIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILES 386
            |.|:|.|..:|:.|.|||:.:...|.|....|||.||||||||.|||.:.|...||...:.:.||
Mouse   324 ITDIFGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYES 388

  Fly   387 MRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEGK 449
            ||.||.:|:...|:.|.:..:.||.||  .:.:..:|  ||:.||..|..||:|.|:||:|.:|.
Mouse   389 MRFSSFLPVTIPHATTANTFVLGYYIP--KNTVVFVNQWSVNHDPAKWPNPEDFDPARFLDKDGF 451

  Fly   450 VRK--PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPES 512
            :.|  ....:.|.||:|.|:|:.|::|.||||.:...|..:....:.:. .::..:.|.||.|:|
Mouse   452 INKALASSVMIFSVGKRRCIGEELSKMLLFLFISILAHQCNFKANQNES-SNMSFSYGLTIKPKS 515

  Fly   513 FKVCLKRR 520
            |::.:..|
Mouse   516 FRIHVSLR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	153/480 (32%)
Cyp1b1	NP_034124.1	p450	51..518	CDD:365848	153/478 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920