Protein Alignment Cyp18a1 and Cyp1a2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034123.1
• Gene: Cyp1a2 / 13077
• MGIID: 88589
• Length: 513
• Species: Mus musculus
• Alignment Length: 510
• Identity: 154/510 - (30%)
• Similarity: 243/510 - (47%)
• Gaps: 42/510 - (8%)

  Fly    23 AQHLLMVFLGLLALVTLLQWLVRNYR----ELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQ 83
            |..||:.    .|:..|:.|:||..|    :..|.||||||||.||::|.:|...|.....|::|
Mouse    10 APELLLA----TAIFCLVFWMVRASRTQVPKGLKNPPGPWGLPFIGHMLTVGKNPHLSLTRLSQQ 70

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECFRR--EEFTGRPDT-PFMQTLNGYGII--NSTGKLWKDQ 143
            ||.:...|:||...||:|....|::...|  ::|.||||. .|....||..:.  ..:|.:|..:
Mouse    71 YGDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAAR 135

  Fly   144 RRFLHDKLRQFGMTYMGNGKQQ--MQKRIMTEVHEFIGHLHASDGQPVDMSPVISV--AVSNVIC 204
            ||...|.|:.|.:.........  :::.:..|.:..:..|..:..:.....||..|  :|:|||.
Mouse   136 RRLAQDALKSFSIASDPTSASSCYLEEHVSKEANHLVSKLQKAMAEVGHFEPVSQVVESVANVIG 200

  Fly   205 SLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHT----VDYIPTMQCFPSISTAKNKIAQNRAEM 265
            ::.....|    |:.......|....:.|.|..|    ||:.|.::..|:.:..:.|...:...:
Mouse   201 AMCFGKNF----PRKSEEMLNIVNNSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKTFNDNFVL 261

  Fly   266 QRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGM 330
              |.|..:.:|.:.|:.|:|:|:........|..|..|       |...||::|.::.|:|.||.
Mouse   262 --FLQKTVQEHYQDFNKNSIQDITSALFKHSENYKDNG-------GLIPEEKIVNIVNDIFGAGF 317

  Fly   331 ETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPL 395
            :|:.|.:.|..:.::..|...|::.:|||.||||.|.|.:.|...||..|:.|||..|.:|.||.
Mouse   318 DTVTTAITWSILLLVTWPNVQRKIHEELDTVVGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPF 382

  Fly   396 ATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEGKV---RKPEY 455
            ...||.|||..|||:.||....:  .||  .|:.|...|:.|..|||.||:......   .:.|.
Mouse   383 TIPHSTTRDTSLNGFHIPKERCI--YINQWQVNHDEKQWKDPFVFRPERFLTNNNSAIDKTQSEK 445

  Fly   456 FIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITP 510
            .:.||:|:|.|:|::.|:.|:|||.|..:...:.::|.|..: .|..|.|.|:.|
Mouse   446 VMLFGLGKRRCIGEIPAKWEVFLFLAILLQHLEFSVPPGVKV-DLTPNYGLTMKP 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	128/444 (29%)
Cyp1a2	NP_034123.1	CYP1A	71..504	CDD:410769	129/445 (29%)