Protein Alignment Cyp18a1 and Cyp1a1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_034122.1
• Gene: Cyp1a1 / 13076
• MGIID: 88588
• Length: 524
• Species: Mus musculus
• Alignment Length: 540
• Identity: 169/540 - (31%)
• Similarity: 265/540 - (49%)
• Gaps: 71/540 - (13%)

  Fly    33 LLALVTLL---QWLVRNYR----ELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFST 90
            ||..||:.   .|:||..|    :..|.||||||||.||::|.:|...|.....|::|||.:...
Mouse    16 LLLAVTVFCLGFWVVRATRTWVPKGLKTPPGPWGLPFIGHMLTVGKNPHLSLTRLSQQYGDVLQI 80

  Fly    91 RLGSQLTVVMSDYKMIRECFRR--EEFTGRPDT-PFMQTLNGYGII--NSTGKLWKDQRRFLHDK 150
            |:||...||:|....|::...|  ::|.||||. .|....||..:.  ..:|.:|..:||...:.
Mouse    81 RIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQNA 145

  Fly   151 LRQFGMT---------YM-------GNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAV 199
            |:.|.:.         |:       .|......:::|.||    ||.        |....:.|:|
Mouse   146 LKSFSIASDPTSASSCYLEEHVSKEANYLVSKLQKVMAEV----GHF--------DPYKYLVVSV 198

  Fly   200 SNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEI----HTVDYIPTMQCFPSISTAKNKIAQ 260
            :||||::....|:..||.:......|..|    |||:    :..|:||.::..|:.|....|...
Mouse   199 ANVICAICFGQRYDHDDQELLSIVNLSNE----FGEVTGSGYPADFIPVLRYLPNSSLDAFKDLN 259

  Fly   261 NRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYL--CEIEKAKAEGTDAELFDGKNHEEQLVQVII 323
            ::  ...|.:.:|.:|.|:|:..:|||:.|..:  |:..|.. |..:.:|.|.|     ::.:::
Mouse   260 DK--FYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRKLD-ENANVQLSDDK-----VITIVL 316

  Fly   324 DLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMR 388
            |||.||.:|:.|.:.|..::::.||:..|::|:|||.|:||.|.|.:.|...||..|:.|||:.|
Mouse   317 DLFGAGFDTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFR 381

  Fly   389 RSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKV--R 451
            .||.||....||.|||..|||:.||.|..|......|:.|..||..|.||||.||:...|.:  |
Mouse   382 HSSFVPFTIPHSTTRDTSLNGFYIPKGCCVFVNQWQVNHDRELWGDPNEFRPERFLTPSGTLDKR 446

  Fly   452 KPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITP---ESF 513
            ..|....||:|:|.|:|:.:.|.|:|||.|..:...:..:..|:.: .:....|.|:..   |.|
Mouse   447 LSEKVTLFGLGKRKCIGETIGRSEVFLFLAILLQQIEFKVSPGEKV-DMTPTYGLTLKHARCEHF 510

  Fly   514 KVCLKRRPLGPTAADPHHMR 533
            :|.::       ::.|.|::
Mouse   511 QVQMR-------SSGPQHLQ 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	141/461 (31%)
Cyp1a1	NP_034122.1	Mitochondrial targeting signal. /evidence=ECO:0000250|UniProtKB:P00185	33..44		2/10 (20%)
		CYP1A	74..509	CDD:410769	140/459 (31%)