Protein Alignment Cyp18a1 and CYP2R1

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_078790.2
• Gene: CYP2R1 / 120227
• HGNCID: 20580
• Length: 501
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 168/517 - (32%)
• Similarity: 253/517 - (48%)
• Gaps: 47/517 - (9%)

  Fly    21 GDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG--YLLFMGSE-KHTRFMELAK 82
            |.|..||:..||:..|:        ..|.....||||.|||.||  |.|...|| .|....:.::
Human    15 GGALFLLLFALGVRQLL--------KQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71

  Fly    83 QYGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINST-GKLWKDQ 143
            .||.:||..||...|||::.|.:::||.  :.|.|..||..| ||:.....|::||. |:.|.|.
Human    72 VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136

  Fly   144 RRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMM 208
            ||...:..|     |.|.|::..:.:|:.|...|...:....|:|.|...:|:.||||:...::.
Human   137 RRLAVNSFR-----YFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196

  Fly   209 STRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIST----AKNKIAQNRAEMQRFY 269
            ..||:.:|..|:....|..|.:.|........|    ..||.|..    ...::.:|.|.:..|.
Human   197 GERFTYEDTDFQHMIELFSENVELAASASVFLY----NAFPWIGILPFGKHQQLFRNAAVVYDFL 257

  Fly   270 QDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKN------HEEQLVQVIIDLFSA 328
            ..:|:....:..|...:..||.||.|:::            |||      .:|.|:..:.:|..|
Human   258 SRLIEKASVNRKPQLPQHFVDAYLDEMDQ------------GKNDPSSTFSKENLIFSVGELIIA 310

  Fly   329 GMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIV 393
            |.||....|.|..:||...|....:||.|:|.::|.:..|:.:|...:|.||:.:.|.:|..:||
Human   311 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375

  Fly   394 PLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIP 458
            ||...|:.:.|..:.||:||.|:.||..:.|||.|...|..||.|.|.||:|:.|...|.|..:|
Human   376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVP 440

  Fly   459 FGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |.:|||.|||:.|||||:||||.:.:..|.:..|. :.:|.||..:|.|:.|:.:.:|.:||
Human   441 FSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDLKPRLGMTLQPQPYLICAERR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	142/443 (32%)
CYP2R1	NP_078790.2	CYP2R1	62..497	CDD:410754	144/456 (32%)