DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2ac1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_017452383.2	Gene:	Cyp2ac1 / 108351992	RGDID:	1564244	Length:	499	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	171/507 - (33%)
Similarity:	271/507 - (53%)	Gaps:	41/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FLGLLALVTLLQWLVRNYREL------RKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSL 87
            |..:|||:.|:..|:.|.::.      |:.||||...||||.|..:..:: :...:||:|:||.:
  Rat     6 FSAILALLGLILILILNIKDFMAKASKRQCPPGPKPWPVIGNLHILNLKRPYQTMLELSKKYGPI 70

  Fly    88 FSTRLGSQLTVVMSDYKMIRECFRR--EEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHD 149
            :|.::|.:..||:|.|:.:::....  .:|..|...|..:.| :|.||..:.|:.||..|||...
  Rat    71 YSIQMGPRKVVVLSGYETVKDALVNYGNQFGERSQVPIFERLFDGKGIAFAHGETWKTMRRFSLS 135

  Fly   150 KLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSI 214
            .||.|||     ||:.::..|:.|....|....:..|:|.::..|::.:|:|||.|:::..||..
  Rat   136 TLRDFGM-----GKRTIEDTIVVECQHLIQSFESHKGKPFEIKRVLNASVANVIVSMLLGKRFDY 195

  Fly   215 DDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSIS---TAKNKIAQNRAEMQRFYQDVIDDH 276
            :||:|.|...||.|.::|.|.    ..|.....||.:.   .:..|:.:||.|:..|.:....:|
  Rat   196 EDPQFLRLLTLIGENIKLIGN----PSIVLFNIFPILGFLLRSHKKVLRNRDELFSFIRRTFLEH 256

  Fly   277 KRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWIN 341
            ..:.|.|:.|..:|.:|  :::.:.....|:.|    :||.|:.::.:||:||.||...||.|..
  Rat   257 CHNLDKNDPRSFIDAFL--VKQQEENNKSADYF----NEENLLALVSNLFTAGTETTAATLRWGI 315

  Fly   342 VFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVE 406
            :.|:|.|:..::|.||:.:|||..: |.||....:|.|::.|.|..|.::|:|.:..|..:.||.
  Rat   316 ILMMRYPEVQKKVHDEIHKVVGSAQ-PRIEHRTQMPYTDAVIHEIQRVANILPTSLPHETSTDVV 379

  Fly   407 LNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVL 471
            ...|.||.|:.||.|:.||..|...||.|:.|.|:.|:.::|:..|.|.|:||.||||||.|:.|
  Rat   380 FKNYYIPKGTEVITLLTSVLRDQTQWETPDAFNPAHFLSSKGRFVKKEAFMPFSVGRRMCAGEPL 444

  Fly   472 ARMELFLFFASFMHCFDIALPEGQPLP-------SLKGNVGATITPESFKVC 516
            |:|||||||.|.|..|..     ||.|       .|..::|.||.|...|:|
  Rat   445 AKMELFLFFTSLMQKFTF-----QPPPGVSYLDLDLTPDIGFTIQPLPHKIC 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	163/477 (34%)
Cyp2ac1	XP_017452383.2	cytochrome_P450	67..490	CDD:425388	149/443 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm45879
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820