DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c50

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_598905.2	Gene:	Cyp2c50 / 107141	MGIID:	2147497	Length:	490	Species:	Mus musculus

Alignment Length:	512	Identity:	181/512 - (35%)
Similarity:	274/512 - (53%)	Gaps:	51/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVF-LGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLF 88
            |::|| |..|.|::|  |  |...|..||||||..||:||.:|.:..:...: |..|:|.||.::
Mouse     5 LVLVFTLSCLFLLSL--W--RQSSERGKLPPGPTPLPIIGNILQINVKDICQSFTNLSKVYGPVY 65

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDK 150
            :..||.:.|||:..|:.::|..  ..|||.||...| |.:..||.|||.|.|.:||:.|||....
Mouse    66 TLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGMGIIFSKGNVWKNTRRFSLTT 130

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||..||     ||:.::.|:..|....:..|..::|.|.|.:.::..|..|||||::...||
Mouse   131 LRNLGM-----GKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRF--- 187

  Fly   216 DPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ-C--FPSI----STAKNKIAQNRAEMQRFYQDVI 273
            |.|.|.|..|:|:    ..||..:...|.:| |  ||.:    ..:.||:.:|.|.::.|..:.|
Mouse   188 DYKDRDFLNLMEK----LNEITKIMSTPWLQVCNTFPVLLDYCPGSHNKVFKNYACIKNFLLEKI 248

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            .:|:.|.|....||.:|::|  |...:..|.    :..||..|.|...:.||||||.||..|||.
Mouse   249 KEHEESLDVTIPRDFIDYFL--INGGQENGN----YPLKNRLEHLAITVTDLFSAGTETTSTTLR 307

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            :..:.:|:.|....:||:|::.|:|:||.|.::|..::|.|::.|.|..|...:||.:..|..|.
Mouse   308 YALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTDAMIHEVQRFIDLVPNSLPHEVTC 372

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLG 468
            |::...|.||.|::||..::||..|...:..||:|.|..|:|..||.:|.:||:||..|:|:|.|
Mouse   373 DIKFRNYFIPKGTNVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAG 437

  Fly   469 DVLARMELFLFFASFMHCFDIALPEGQPL---------PSLKGNVGATITPESFKVC 516
            :.|||||||||..|.:..|::     :||         |.|   :|....|.:|::|
Mouse   438 EGLARMELFLFLTSILQNFNL-----KPLVHPKDIDVTPML---IGLASVPPAFQLC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	169/483 (35%)
Cyp2c50	NP_598905.2	p450	30..487	CDD:278495	169/483 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820