Protein Alignment Cyp18a1 and Cyp2c50

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_598905.2
• Gene: Cyp2c50 / 107141
• MGIID: 2147497
• Length: 490
• Species: Mus musculus
• Alignment Length: 512
• Identity: 181/512 - (35%)
• Similarity: 274/512 - (53%)
• Gaps: 51/512 - (9%)

  Fly    26 LLMVF-LGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLF 88
            |::|| |..|.|::|  |  |...|..||||||..||:||.:|.:..:...: |..|:|.||.::
Mouse     5 LVLVFTLSCLFLLSL--W--RQSSERGKLPPGPTPLPIIGNILQINVKDICQSFTNLSKVYGPVY 65

  Fly    89 STRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDK 150
            :..||.:.|||:..|:.::|..  ..|||.||...| |.:..||.|||.|.|.:||:.|||....
Mouse    66 TLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGMGIIFSKGNVWKNTRRFSLTT 130

  Fly   151 LRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSID 215
            ||..||     ||:.::.|:..|....:..|..::|.|.|.:.::..|..|||||::...||
Mouse   131 LRNLGM-----GKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQDRF--- 187

  Fly   216 DPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ-C--FPSI----STAKNKIAQNRAEMQRFYQDVI 273
            |.|.|.|..|:|:    ..||..:...|.:| |  ||.:    ..:.||:.:|.|.::.|..:.|
Mouse   188 DYKDRDFLNLMEK----LNEITKIMSTPWLQVCNTFPVLLDYCPGSHNKVFKNYACIKNFLLEKI 248

  Fly   274 DDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLL 338
            .:|:.|.|....||.:|::|  |...:..|.    :..||..|.|...:.||||||.||..|||.
Mouse   249 KEHEESLDVTIPRDFIDYFL--INGGQENGN----YPLKNRLEHLAITVTDLFSAGTETTSTTLR 307

  Fly   339 WINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTR 403
            :..:.:|:.|....:||:|::.|:|:||.|.::|..::|.|::.|.|..|...:||.:..|..|.
Mouse   308 YALLLLLKYPHVTAKVQEEIEHVIGKHRRPCMQDRSHMPYTDAMIHEVQRFIDLVPNSLPHEVTC 372

  Fly   404 DVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLG 468
            |::...|.||.|::||..::||..|...:..||:|.|..|:|..||.:|.:||:||..|:|:|.|
Mouse   373 DIKFRNYFIPKGTNVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFSTGKRICAG 437

  Fly   469 DVLARMELFLFFASFMHCFDIALPEGQPL---------PSLKGNVGATITPESFKVC 516
            :.|||||||||..|.:..|::     :||         |.|   :|....|.:|::|
Mouse   438 EGLARMELFLFLTSILQNFNL-----KPLVHPKDIDVTPML---IGLASVPPAFQLC 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	155/448 (35%)
Cyp2c50	NP_598905.2	CYP2C-like	61..485	CDD:410758	156/449 (35%)