DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and LOC103909721

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_009295398.2	Gene:	LOC103909721 / 103909721	-ID:	-	Length:	504	Species:	Danio rerio

Alignment Length:	525	Identity:	171/525 - (32%)
Similarity:	279/525 - (53%)	Gaps:	53/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DAQHLLMVFLGLLALVTLLQWLVRNYREL--RKLPPGPWGLPVIGYLLFMG-SEKHTRFMELAKQ 83
            |.|..| :||.:|.       ||:::|::  ..:||||:.||.:|.:|.:| .:....|.::|::
Zfish    14 DVQGFL-IFLSVLL-------LVKHFRDVFTNNMPPGPFPLPFVGNVLSIGFGDPMEVFPKVAEK 70

  Fly    84 YGSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRR 145
            ||.:.:..:|::..::|:.|::.:|.|  :.:.||.||..|....: .|.|:|.|.|.:.:.|||
Zfish    71 YGDVCTFYIGTKPCILMTGYEVFKEAFVEQADIFTDRPFFPVNDRICKGKGLIFSGGHMCRQQRR 135

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMST 210
            |....|:.||:     ||:.::..|:.|.......:.:..|.|.:...:::.||.||||||:...
Zfish   136 FALATLKYFGV-----GKKTLENSILQECRSVCESVQSERGLPFNPHYILTYAVGNVICSLVFGY 195

  Fly   211 RFSI--DDPKFRRFNFLIEEG-------MRLFGEIHTVDYIPTMQCFPSIS---TAKNKIA-QNR 262
            :|..  ||     ||.|::..       :.::|.::        ..|||:.   ..|::.| .|.
Zfish   196 KFDYGNDD-----FNKLLDYSDDTFKLPINIWGRLY--------NAFPSVMPLLPGKHQTAFANL 247

  Fly   263 AEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFS 327
            .:::.|:|:.|:.||.:.:|.:.||.:|.||.||||.|.:  :||.     .||.|:..::|||.
Zfish   248 TKLKLFFQEEINKHKENRNPYSPRDYIDCYLEEIEKCKDK--EAEF-----TEENLIHCVLDLFG 305

  Fly   328 AGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSI 392
            ||.|:...||:|..::|.:.|....:|..|:|||:|:.|.|.:||..:||.|.:.:.|..|.:::
Zfish   306 AGTESTAKTLVWALLYMAKYPDVQEKVHTEIDQVIGQSRQPLMEDRAHLPYTYAVMHEVQRFANV 370

  Fly   393 VPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFI 457
            :........::|..:.|:.||.|..|:|::..:..|.|.:..|.||.|:.|:|..||..|.|.||
Zfish   371 LAFIPPRVASKDTTVAGFLIPKGVMVLPMLKPILEDKNEYCTPNEFNPAHFLDENGKFVKRENFI 435

  Fly   458 PFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPL 522
            ||.:|:|||.|:.||.|||||||.|.|..|....|||:.| |||..|.....|..|::....|..
Zfish   436 PFSIGKRMCPGEQLAGMELFLFFISLMQHFTFLPPEGETL-SLKRTVAIASAPAPFRIKAVPRQC 499

  Fly   523 GPTAA 527
            ..||:
Zfish   500 DNTAS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	159/479 (33%)
LOC103909721	XP_009295398.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820