Protein Alignment Cyp18a1 and cyp2k6

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: XP_012819567.2
• Gene: cyp2k6 / 100490986
• XenbaseID: XB-GENE-29080475
• Length: 489
• Species: Xenopus tropicalis
• Alignment Length: 500
• Identity: 162/500 - (32%)
• Similarity: 274/500 - (54%)
• Gaps: 33/500 - (6%)

  Fly    29 VFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFSTRL 92
            |.|.::..:.|.:......|.|...||||..||:||.|..|..:| |..|||||::|||:||..|
 Frog     6 VLLSVVVCIFLFKVFYGGKRTLENFPPGPKPLPLIGNLHMMNMKKPHLTFMELAEKYGSVFSVHL 70

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDKLRQF 154
            |::..||:.....:|:..  ..|||:.|...|..:..: |.|::...|:.||..|||....||.|
 Frog    71 GTEKVVVLCGTDTVRDALINHAEEFSERAKMPIFEDFSKGLGVVFGHGENWKVMRRFTLSTLRDF 135

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            ||     ||:.:::||..|....:..:.:.:|:|.|.:.:::.||:|:|..::::.||...||..
 Frog   136 GM-----GKKTIEERISEESDCLVETIKSYEGKPFDNTLIMNAAVANIIVHILLNHRFDYQDPTL 195

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
            .:...::.:.:::.|....:.|    ..:||    |..:...:.:|.|::.:|.::....|:...
 Frog   196 LKLINIVIDNIKIGGSPIVMLY----NTYPSVVRWIPGSHKTLGENTAQLYKFLEETFTQHREQL 256

  Fly   281 DPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFML 345
            |.|:.|||:|.:|  :::.:.:.:.|:.|    |.|.||.::.:||.|||||..|||.|..:.|:
 Frog   257 DVNDQRDLIDAFL--VKQQEEKPSSAKFF----HNENLVALLANLFVAGMETSSTTLRWGLLLMM 315

  Fly   346 RNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGY 410
            :.|...::||||:|:|:|... |.:|..:.:|.|::.|.|..|.::|.|::..|:.|.||...||
 Frog   316 KYPDIQKKVQDEIDRVIGSVE-PRLEHRKLMPYTDAVIHEIQRFANIAPISLPHATTTDVTFRGY 379

  Fly   411 TIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARME 475
            .||..:.|:.::.||..|.:.::|||:|.|..|::::|...|.|.|:||..|||:|.|:.||:||
 Frog   380 FIPKDTQVMIVLTSVLRDKDYFKKPEDFYPEHFLNSKGNFVKNEAFLPFSAGRRICAGETLAKME 444

  Fly   476 LFLFFASFMHCFDIALPEGQPLPSLKGNV----GATITPESFKVC 516
            |||||...:..|..     ||.|.::.::    ..|..|:..::|
 Frog   445 LFLFFTKLLQNFTF-----QPPPGVEVDLTCADAMTSKPQEHQIC 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	138/440 (31%)
cyp2k6	XP_012819567.2	cytochrome_P450	62..483	CDD:477761	139/441 (32%)