DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp1b1

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001038721.1	Gene:	cyp1b1 / 100150054	ZFINID:	ZDB-GENE-030902-1	Length:	526	Species:	Danio rerio

Alignment Length:	510	Identity:	153/510 - (30%)
Similarity:	261/510 - (51%)	Gaps:	34/510 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLALVTLLQWLVRN------------YRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYG 85
            ||||..|||...|:            :|. |:|.|||:..||||....:|:..|..|..:|::||
Zfish     5 LLALRDLLQLSTRSVLLSLMVCLMLMFRR-RQLVPGPFSWPVIGNAAQLGNTPHFYFSRMAQKYG 68

  Fly    86 SLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPD-TPFMQTLNGYGII--NSTGKLWKDQRR 145
            .:|..:|||:..||::. ..|:|..  :..:|.|||| ..|....||..:.  |.| ..||..|:
Zfish    69 DVFQIKLGSRNVVVLNG-DAIKEALVKKATDFAGRPDFASFRFVSNGKSMAFGNYT-PWWKLLRK 131

  Fly   146 FLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSP--VISVAVSNVICSLMM 208
            .....:|.|....: ..||..:|.|::|:.|.|........:.....|  .:.|:|:|.:.::..
Zfish   132 VAQSTVRNFSTANI-QTKQTFEKHIVSEIGELIRLFLNKSREQQFFQPHRYLVVSVANTMSAVCF 195

  Fly   209 STRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNKIAQNRAEMQRFYQDV 272
            ..|::.||.:|::.....::..:..|....||.:|.||.||: |.|..::..:...|...|.:..
Zfish   196 GNRYAYDDAEFQQVVGRNDQFTKTVGAGSMVDVMPWMQYFPNPIRTLFDQFKELNKEFCAFIELK 260

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            :.:|:::..|:::||:.|.::..::|..:.|:...|     .:|.:...|.|:|.|..:|:.|.|
Zfish   261 VSEHRKTISPSHVRDMTDAFIVALDKGLSGGSGVSL-----DKEFVPPTISDIFGASQDTLSTAL 320

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .||.:.::|.|:...|:|:::.:||.|.|||||.|..:||...:.|.|.||.:|..||...||.|
Zfish   321 QWIILLLVRYPEIQNRLQEDVGRVVDRSRLPTIADQPHLPYLMAFIYEVMRFTSFTPLTIPHSTT 385

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRK--PEYFIPFGVGRRM 465
            :|..:|||.||..:.:.....|::..|..|::||.|.|.||:|.:|.:.|  ....:.|.:|:|.
Zfish   386 KDTSINGYPIPKDTVIFVNQWSLNHAPAKWDQPEVFNPQRFLDEDGSLNKDLTTNVLIFSLGKRR 450

  Fly   466 CLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRR 520
            |:|:.:::::||||.:..:|....   :.:..|::....|.|:.|:.|||.:..|
Zfish   451 CIGEDVSKIQLFLFTSVLVHQCSF---KAESTPNMDYEYGLTLKPKPFKVSVTAR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	141/472 (30%)
cyp1b1	NP_001038721.1	p450	38..499	CDD:278495	141/471 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920