DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp1c2

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001108321.1	Gene:	cyp1c2 / 100137725	ZFINID:	ZDB-GENE-050705-1	Length:	454	Species:	Danio rerio

Alignment Length:	463	Identity:	147/463 - (31%)
Similarity:	231/463 - (49%)	Gaps:	27/463 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 MGSEKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRRE--EFTGRPDTPFMQTLNGYG 131
            :|...|..|.:|||:||:::..||||...||::....||....:.  ||.|||:....|.::|..
Zfish     3 LGQMPHITFSKLAKKYGNVYQIRLGSSDIVVLNGESAIRSALLQHSTEFAGRPNFVSFQYVSGGT 67

  Fly   132 IIN--STGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPV 194
            .:.  |..|.||..|:.....:|.|. :.....|:..:|.|:.|..:.:.....|  |..:.|..
Zfish    68 SMTFASYSKQWKMHRKIAQSTIRAFS-SANSRTKKSFEKHIVAEAVDLVETFLKS--QHFNPSHE 129

  Fly   195 ISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS-ISTAKNKI 258
            ::||.:|:||:|....|:..||.:||.....:.......|....||.:|.:|.||: |.:.....
Zfish   130 LTVAAANIICALCFGKRYGHDDLEFRTLLGNVNRFSETVGAGSLVDVMPWLQTFPNPIRSIFQSF 194

  Fly   259 AQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEG--TDAELFDGKNHEEQLVQV 321
            .....:...|.:..:.:|:.|:||..|||:.|.::..::.|..|.  |:|       |.|..|.
Zfish   195 KDLNNDFFSFVKGKVVEHRLSYDPEVIRDMSDAFIGVMDHADEETGLTEA-------HTEGTVS- 251

  Fly   322 IIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILES 386
              ||..||::|:.|.|.|:.:.:::.|....::|:::|:||||.|||:|||...|...::.|.|:
Zfish   252 --DLIGAGLDTVSTALNWMLLLLVKYPSIQSKLQEQIDKVVGRDRLPSIEDRCNLAYLDAFIYET 314

  Fly   387 MRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLIN--SVHMDPNLWEKPEEFRPSRFIDTEGK 449
            ||.:|.||:...||.|.||.:.|..||  ...:..||  ||:.||..|..|..|.||||:|..|.
Zfish   315 MRFTSFVPVTIPHSTTSDVTIEGLHIP--KDTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENGA 377

  Fly   450 VRK--PEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPES 512
            :.|  ....:.|.:|||.|:||.:|::|:||..|..:|.........|.| :|..:.|.|:.|..
Zfish   378 LDKDLTSSVMIFSIGRRRCIGDQIAKVEVFLISAILIHQLTFESDPSQDL-TLNCSYGLTLKPFD 441

  Fly   513 FKVCLKRR 520
            :|:..|.|
Zfish   442 YKISAKPR 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	145/458 (32%)
cyp1c2	NP_001108321.1	p450	4..444	CDD:278495	144/455 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820