Protein Alignment Cyp18a1 and cyp2a6.2

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001106451.1
• Gene: cyp2a6.2 / 100127628
• XenbaseID: XB-GENE-5892300
• Length: 494
• Species: Xenopus tropicalis
• Alignment Length: 501
• Identity: 155/501 - (30%)
• Similarity: 264/501 - (52%)
• Gaps: 39/501 - (7%)

  Fly    34 LALVTLLQWLVRNY---RELRK--LPPGPWGLPVIGYLLFMGSEKHTR-FMELAKQYGSLFSTRL 92
            |.|..::.:||.::   |:|||  :||||...|::|.:|.:.:::..: .::|:::||::|:..|
 Frog     9 LILAVIVSFLVYSFTWRRKLRKINMPPGPPLYPLLGNMLQISAKEFPQSLVKLSEKYGTVFTVYL 73

  Fly    93 GSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTL-NGYGIINSTGKLWKDQRRFLHDKLRQF 154
            .|:..|::|.|..|:|..  ..|.|..|.::|....| ..||:|.|.|:.||..|||....||.|
 Frog    74 PSKPAVILSGYDCIKEALLDNNESFGARGESPLGYLLFKDYGVIFSNGERWKQLRRFSLSCLRDF 138

  Fly   155 GMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKF 219
            ||     ||:.:::||..|....:..|..:...|:|.:.::::|||||||:::...||...|.||
 Frog   139 GM-----GKKSIEERIQEEARCLVEELGKNGDTPMDPTYMLTLAVSNVICTVVFGERFDYKDEKF 198

  Fly   220 RRFNFLIEEGMRLFGEIHTVDYIPTMQCFPS----ISTAKNKIAQNRAEMQRFYQDVIDDHKRSF 280
            .....|::...|.|.....:    .:..||:    :.....::.:|..:::.|..:.:..|:.:.
 Frog   199 MTLISLLKIVSRDFSSAWGI----LLNLFPNTLSRLPGPPQRLFRNFDKLKAFVAESLKSHQETL 259

  Fly   281 DPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFML 345
            :.:..||.:|.:|.::||.| .....|.     |.:.|...::|||.||.||...||.:..:.:|
 Frog   260 NSDCPRDFIDCFLIKMEKEK-NNPQTEF-----HSDNLFGTVLDLFFAGTETTSITLKYSFLMLL 318

  Fly   346 RNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGY 410
            :..:..|:..:|:|.::|:.|.|..||...:|.|.:.|.|..|.:.||||...|:.|.|:...||
 Frog   319 KYTEVTRKAMEEIDNIIGQERCPFYEDRIKMPYTNAVIHEIQRMADIVPLGVPHATTHDIIFRGY 383

  Fly   411 TIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARME 475
            .||..:.:.||:.||..||..:..|::|.|:.|:|..|..:|.:.|.||.:|:|.|||:.|||||
 Frog   384 NIPKDTIIFPLMTSVLKDPKYFNDPKQFDPAHFLDENGSFKKNDAFQPFSIGKRSCLGEGLARME 448

  Fly   476 LFLFFASFMHCFDI---ALPEG---QPLPSLKGNVGATITPESFKV 515
            :|||..|.:..|::   ..|:.   .|.|...|.:     |.::|:
 Frog   449 IFLFITSILQAFNLKSDTAPQDIDITPEPDKNGAI-----PRTYKM 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	137/442 (31%)
cyp2a6.2	NP_001106451.1	cytochrome_P450	65..489	CDD:477761	138/443 (31%)