Protein Alignment Cyp18a1 and Cyp2j11

DIOPT Version :10

• Sequence 1: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001004141.2
• Gene: Cyp2j11 / 100066
• MGIID: 2140224
• Length: 504
• Species: Mus musculus
• Alignment Length: 504
• Identity: 163/504 - (32%)
• Similarity: 259/504 - (51%)
• Gaps: 29/504 - (5%)

  Fly    23 AQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMG---SEKHTRFMELAKQY 84
            |.||..:.|.||.|:.|..:| :| |..:..||||..||.:|.|....   |..|.......|:|
Mouse    15 AIHLWTLLLTLLTLLLLADYL-KN-RRPKNYPPGPRRLPFVGNLFQFDLDVSRLHLGIQPFVKKY 77

  Fly    85 GSLFSTRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQ-TLNGYGIINSTGKLWKDQRRF 146
            |::.|...|...:|::|...:|:|..  ..:.|..||.....| .....||:.|:|:.||:||:|
Mouse    78 GNVISVNFGYISSVIISGLPLIKEAITGMEQNFLKRPSLAARQHVFKNNGIVFSSGQTWKEQRKF 142

  Fly   147 LHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTR 211
            ....|:.||:     ||:.:::.|..|.:..:..:....|||.|....|:.||.|:|||::...|
Mouse   143 ALTILKNFGL-----GKKSLEQCIQEEAYHLVKAIGEEKGQPFDPHFRINNAVGNIICSIIFGER 202

  Fly   212 FSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSI----STAKNKIAQNRAEMQRFYQDV 272
            |..||.:|:....|.:|.:.....:.:|.|    ..||||    ...:.|:..|..:::.|...:
Mouse   203 FEYDDNQFQELLKLADEIICSEASMMSVLY----NVFPSIFKYLPGPQQKLFSNWEKLKLFVSRM 263

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            :|.|:..::|:..||.:|.:|.|:.|...:.|.:      .:||.|:...:|||.||.||...||
Mouse   264 MDSHREDWNPSAPRDFIDAFLTEMTKYPDKTTTS------FNEENLICTALDLFFAGTETTSNTL 322

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .|..:::..||:...:|..|:|:|:|..|.||::|...:|.|.:.|.|.:|..:|:||......|
Mouse   323 RWALLYITVNPEVQEKVHSEIDRVIGHGRHPTLDDQDSMPYTNAVIHEVLRMGNIIPLNVPREVT 387

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            .|..|.|:.:|.|:.|:..:..:|.||..|:.|..|.|..|:: .|:.:|.|.|:||.:|:|.|.
Mouse   388 ADSTLAGFYLPKGTMVLINLTDLHRDPKEWDTPNVFNPEHFLE-NGQFKKKESFLPFSMGKRACP 451

  Fly   468 GDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            |:.||..|||:||.:.|..|....|..:. ||||..:|.|:.|.|:::|
Mouse   452 GEQLASCELFIFFTALMQKFTFKSPINEK-PSLKFRMGLTLAPVSYRIC 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	139/436 (32%)
Cyp2j11	NP_001004141.2	cytochrome_P450	77..498	CDD:477761	140/437 (32%)