DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	509	Identity:	154/509 - (30%)
Similarity:	249/509 - (48%)	Gaps:	46/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIG-YLLFMGSEKHTRFMELAKQYGSLFS 89
            :|::.|..:.|::|  |..|:.|  |.|||||..||:|| |.|....:........:|.||.:|:
Mouse     6 VLVLCLSFMLLLSL--WRQRSAR--RNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFT 66

  Fly    90 TRLGSQLTVVMSDYKMIRECF--RREEFTGRPDTPFMQTLN-GYGIINSTGKLWKDQRRFLHDKL 151
            ...|||..||:..|:.|:|..  ..|.|:||...||...:: |.||..|.|.:||..|.|..:.|
Mouse    67 LYFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSKGKGIGFSHGNVWKATRVFTVNTL 131

  Fly   152 RQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDD 216
            |...|     ||:.::.::..|....:..|..::|.|.|...:|..|..|||||::...||...|
Mouse   132 RNLAM-----GKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKD 191

  Fly   217 PKFRRF--------NFLIEEGMRLFGEIH-TVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDV 272
            ..|...        ..|...|.::|..:. .:||.|...         ||..:|...::.:..:.
Mouse   192 KDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGRH---------NKFFKNHTWIKSYLLEK 247

  Fly   273 IDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHE----EQLVQVIIDLFSAGMETI 333
            |.:|:.|.|..|.||.:|::|.:..:.|          |..|.    |.|..::.||...|.||:
Mouse   248 IKEHEESLDVTNPRDFIDYFLIQRRQDK----------GIEHMEYTIEHLATLVTDLVFGGTETL 302

  Fly   334 KTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATT 398
            .:|:.:..:.::::.....:||:|:|.|:||||.|.::|.:::|.|.:.:.|..|...:.|.:..
Mouse   303 SSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRKHMPYTNAMVHEVQRYVDLGPTSLV 367

  Fly   399 HSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGR 463
            |..|.|.:...|.||.|:.|:..::||..|...:..||.|.|..|:|..|..:|.:||:||..|:
Mouse   368 HEVTCDTKFRNYFIPKGTQVMTSLSSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGK 432

  Fly   464 RMCLGDVLARMELFLFFASFMHCFDI-ALPEGQPLPSLKGNVGATITPESFKVC 516
            |:|:|:.|||||||||..:.:..|.: .|.:.:.:.:.....|.:..|..|::|
Mouse   433 RICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDTTPKYSGFSKIPPKFQMC 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	145/481 (30%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	145/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820