DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp18a1 and cyp2p7

DIOPT Version :9

Sequence 1:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001076518.1	Gene:	cyp2p7 / 100034406	ZFINID:	ZDB-GENE-041001-155	Length:	496	Species:	Danio rerio

Alignment Length:	504	Identity:	178/504 - (35%)
Similarity:	265/504 - (52%)	Gaps:	44/504 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEK-HTRFMELAKQYGSLFST 90
            |:|||       .|...:|| :..:..|||||.||.||::..:..:| |.:|::.|::||.:||.
Zfish    19 LVVFL-------FLSDYIRN-KSPKNFPPGPWSLPFIGHIHHIEHKKVHLQFLKFAEKYGKIFSI 75

  Fly    91 RLGSQLTVVMSDYKMIRECF--RREEFTGRPDTP-FMQTLNGYGIINSTGKLWKDQRRFLHDKLR 152
            ||.....||:..||:::|.:  :.:....||..| |.......|:|.|.|..||.||||.....|
Zfish    76 RLFGPRIVVLDGYKLVKEVYLQQGDNLADRPILPMFYDITEDKGLIGSNGYKWKHQRRFALSTFR 140

  Fly   153 QFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDP 217
            .||:     ||:.::..|:.|............|:|.|...:::.|||||||:|:.|.||...|.
Zfish   141 TFGL-----GKKSLEPSILLECSCLNDAFSNEQGRPFDPRLLLNNAVSNVICALVFSNRFDYSDH 200

  Fly   218 KFRRFNFLIEEGMRLFGEI--HTVDYIP-TMQCFP----SISTAKNKIAQNRAEMQRFYQDVIDD 275
            .|:.....|.|.:.|.|.:  ...::.| .|:..|    .|....||:..       |.::.:::
Zfish   201 HFQTLLKHINEVLYLEGTVWAQLYNFFPWLMRRLPGPHQKIFVLLNKVID-------FVREKVNE 258

  Fly   276 HKRSFDPNNIRDLVDFYLCEIEKAK---AEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTL 337
            |:..:||:|.||.:|.:|.|:||.|   |.|.|.         |.|....:|||.||.||..|||
Zfish   259 HRVDYDPSNPRDYIDCFLAEMEKLKDDTAAGFDV---------ENLCICTLDLFVAGTETTSTTL 314

  Fly   338 LWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPT 402
            .|..:::::.|:...:||.|:|.|||..|.|::.|...:|.|.:.|.|..|..:||||.......
Zfish   315 YWGLLYIIKYPEIQAKVQQEIDAVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIVPLNVFRITV 379

  Fly   403 RDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCL 467
            .|.::..|:||.|:.||..:.||..|.:.||.|..|.|..|:|.|||.|:.:.|:||.:|:|:||
Zfish   380 EDTQIGEYSIPKGTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCL 444

  Fly   468 GDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVC 516
            |:.||||||||||:|.:..|..:.|.|.. |||...:|.|.:|:.:|:|
Zfish   445 GEQLARMELFLFFSSLLQRFTFSPPAGVE-PSLDYKLGGTHSPQPYKLC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	171/477 (36%)
cyp2p7	NP_001076518.1	p450	38..492	CDD:278495	170/475 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC78
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	1	1.000	-	-		otm24427
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720