DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and cyp2j20

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_001337781.3	Gene:	cyp2j20 / 797309	ZFINID:	ZDB-GENE-041210-324	Length:	496	Species:	Danio rerio

Alignment Length:	544	Identity:	151/544 - (27%)
Similarity:	244/544 - (44%)	Gaps:	77/544 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFE 85
            |||:    .|.|.|.|.:...|......|||||.||.:|.:..:|....|..|.:.|::||.||.
Zfish    14 SILI----FVCVFLLLSDFIKNKTPKNFPPGPWSLPIIGDIHHIDPSKLHLQLSEFAEKYGKIFS 74

  Fly    86 LKMGRVPTVVLSDAALVRDFFRR--DVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWL 148
            |::.....|||:...||::.:.:  |.:..||.|.|.|.|:|..|::.:....|:..||..:..|
Zfish    75 LRLFGPRIVVLNGYNLVKEVYTQEGDNLADRAILPLFHDIIGDKGLVASSGYKWKQQRRFALSTL 139

  Fly   149 KALGMTRRPGELRARLERRIARGVDECVRLFDTEA-KKSCASEVNPLPALHHSLGNIINDLVFGI 212
            :..|:.::..|....||..           |..|| ........:|...|::::.|:|..||||.
Zfish   140 RNFGLGKKNLEPSINLESG-----------FLNEAISNEQGQPFDPRLLLNNAVSNVICALVFGN 193

  Fly   213 TYKRDDPDWLYLQRLQEEGVKLIG--VSGVVNFLPWL-RHLPANVRNIRFLLEGKAKTHAIYDRI 274
            .:...|..:..|.:...|.|.|.|  .:.:.|.|||| |.||...:.|          .|::.::
Zfish   194 RFDYSDHKFQTLLKNINETVHLEGGICAQLYNMLPWLMRLLPGPHKRI----------IALWGKL 248

  Fly   275 VEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEAD--EDDEESDEEDTYEP 337
            :|..|:::.| .||                       :.||...:...|  .|:.|..::||
Zfish   249 IEFVGEKVNE-HKV-----------------------DHDPLNPRDYIDCFLDEMEKHKDDT--- 286

  Fly   338 ECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRL-HELLL 401
                   .|..|.::...|       ..|||.||.:|:..||.|.|||:.:....|.:: .|:.:
Zfish   287 -------AAGFDVENLCIC-------TLDLFVAGTETTSTTLYWGLLYMMKYPEIQAKVQQEIDV 337

  Fly   402 PLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAI 464
            .:|.|  |::.:.:.:.|..|.|.|..|:.:::|:.:.....|:..:..|.|..|:|:..:..::
Zfish   338 IVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIIPINLARTTSEDTQIEKYSIPKGTMVTSNLTSV 402

  Fly   465 HMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLE 529
            ..|...:..|..|.|..||.|:|.::....|:|||.|.|:|.||::|||.|.||...:|:||...
Zfish   403 LFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCLGEQLARMELFLFFSSLLQRFTFS 467

  Fly   530 LPSGTEVDMAGESGITLTPTPHML 553
            .|:|.|..:....|.|..|.|:.|
Zfish   468 PPAGVEPSLDYNLGATHCPQPYKL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	143/516 (28%)
cyp2j20	XP_001337781.3	p450	38..492	CDD:278495	143/516 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910