Protein Alignment phtm and Cyp2d26

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_083838.1
• Gene: Cyp2d26 / 76279
• MGIID: 1923529
• Length: 500
• Species: Mus musculus
• Alignment Length: 555
• Identity: 147/555 - (26%)
• Similarity: 229/555 - (41%)
• Gaps: 105/555 - (18%)

  Fly    28 ALVLVILYLCERQ-----CNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELK 87
            |:.|:::.|..|:     |.      ||||...|.||.|..:|......|..||..|||.:|.|:
Mouse    17 AIFLLLVDLVHRRQRWTACY------PPGPVPFPGLGNLLQVDFENIPYSFYKLQNRYGNVFSLQ 75

  Fly    88 MGRVPTVVLSDAALVRDF---FRRDVMTGRAPLYLTHGIMGGFG------IICAQEDIWRHARRE 143
            |...|.||::....||:.   :..|  |...||...:..: |:|      |:......||..||.
Mouse    76 MAWKPVVVVNGLKAVRELLVTYGED--TSDRPLMPIYNHI-GYGHKSKGVILAPYGPEWREQRRF 137

  Fly   144 TIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDL 208
            ::..|:..|:.::      .||:.:..........|..||:    ...||.|.|..::.|:|..|
Mouse   138 SVSTLRDFGLGKK------SLEQWVTEEAGHLCDAFTKEAE----HPFNPSPLLSKAVSNVIASL 192

  Fly   209 VFGITYKRDDPDWLYLQRLQEEGVKLIG-----VSGVVNFLPWLRHLPANVRNIRFLLEGKAKTH 268
            ::...::.:||   :..|:.:...:.:|     |..|:|.:|.|.|:|.        |..||
Mouse   193 IYARRFEYEDP---FFNRMLKTLKESLGEDTGFVGEVLNAIPMLLHIPG--------LPDKA--- 243

  Fly   269 AIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEED 333
                                |.:|.....|   :.|..:......||:|
Mouse   244 --------------------FPKLNSFIAL---VNKMLIEHDSTWDPAQ---------------- 269

  Fly   334 TYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQR 394
              .|..:.:.|||    .:......:.|..||.::.|||.||:.|:..||.|.||.:......||
Mouse   270 --PPRDLTDAFLAEVEKAKGNPESSFNDKNLRIVVIDLFMAGMVTTSTTLSWALLLMILHPDVQR 332

  Fly   395 RLH-ELLLPLG--PSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSM 456
            |:| |:...:|  ..|.:.:...:.|..|.|.|..|...:||..:||....:....|:||..|:.
Mouse   333 RVHQEIDEVIGHVRHPEMADQARMPYTNAVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTT 397

  Fly   457 IVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGR 521
            ::.:..::..|...:.:|..|.||.||.|.|.:.....|:|||:|.|.|.||.:|||.|.||...
Mouse   398 LIPNLSSVLKDETVWEKPLRFYPEHFLDAQGHFVKHEAFMPFSAGRRSCLGEPLARMELFLFFTC 462

  Fly   522 ILRRFHLELPSGTEVDMAGESGI---TLTPTPHML 553
            :|:||...:|.|.  ....:.||   .:||.|:.|
Mouse   463 LLQRFSFSVPDGQ--PRPSDYGIYTMPVTPEPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	127/495 (26%)
Cyp2d26	NP_083838.1	CYP2D	68..495	CDD:410756	128/496 (26%)