DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2c55

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_082365.1	Gene:	Cyp2c55 / 72082	MGIID:	1919332	Length:	490	Species:	Mus musculus

Alignment Length:	564	Identity:	144/564 - (25%)
Similarity:	227/564 - (40%)	Gaps:	112/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIF 84
            |.::|....|:|:.|:   || |...|..||||...|.:|.:..:|.:...||....:|.||.:|
Mouse     5 LVLVLTLSCLLLLSLW---RQ-NSGRGKLPPGPTPFPIIGNILQIDIKNISKSFNYFSKVYGPVF 65

  Fly    85 ELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDW 147
            .|..|..||||:.....|::..  ..:..:||....:...|....|:|.:....|:..||.:|..
Mouse    66 TLYFGSKPTVVVHGYEAVKEALDDLGEEFSGRGSFQIFERINNDLGVIFSNGTKWKELRRFSIMT 130

  Fly   148 LKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGI 212
            |::.||.:|      .:|.||.   :|...|.: |.:|:..|..:|...|..:..|:|..::|..
Mouse   131 LRSFGMGKR------SIEDRIQ---EEASCLVE-ELRKANGSLCDPTFILSCAPSNVICSVIFHN 185

  Fly   213 TYKRDDPDWLYLQRLQEEGVKLIGV--SGVVNFLPWL-RHLPA-------NVRNIRFLLEGKAKT 267
            .:...|..:|.|.....|..|::..  ..|.|.||.| .:||.       |...|:..:.|:.|.
Mouse   186 RFDYKDEKFLNLMERLNENFKILNSPWMQVYNALPTLINYLPGSHNKVIKNFTEIKSYILGRVKE 250

  Fly   268 HAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESD-- 330
            |                                                ||..:.|...:..|
Mouse   251 H------------------------------------------------QETLDMDNPRDFIDCF 267

  Fly   331 ----EEDTYEP--ECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLARE 389
                |::.:.|  |..:|..:|.                :.|:|.||.:|:..|||:.||.|.:.
Mouse   268 LIKMEQEKHNPHSEFTIESLMAT----------------VTDIFVAGTETTNITLRYGLLLLLKH 316

  Fly   390 QRCQRRLH-ELLLPLG--PSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFI 451
            .....::. |:...:|  .||.:::...:.|..|.:.|..|...::|..:||....|.....|||
Mouse   317 TEVTAKVQAEIDHVIGRHRSPCMQDRTRMPYTDAMVHEIQRYIDLIPNNVPHAATCNVRFRSYFI 381

  Fly   452 KGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILT 516
            ..|:.:|.|..::..|...||.||.|.|..||..:|.::....|:|||.|.|||.||.:||..|.
Mouse   382 PKGTELVTSLTSVLHDDKEFPNPEVFDPGHFLDENGNFKKSDYFMPFSIGKRMCVGEALARTELF 446

  Fly   517 LFTGRILRRFHLE-LPSGTEVDMAGESGITLTPTPHMLRFTKLP 559
            |....||:.|:|: |....::|          .||....|.::|
Mouse   447 LILTTILQNFNLKSLVDTKDID----------TTPVANTFGRVP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	133/529 (25%)
Cyp2c55	NP_082365.1	p450	30..485	CDD:278495	135/535 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000