Protein Alignment phtm and CYP2W1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: XP_011513742.1
• Gene: CYP2W1 / 54905
• HGNCID: 20243
• Length: 564
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 142/537 - (26%)
• Similarity: 227/537 - (42%)
• Gaps: 83/537 - (15%)

  Fly    19 SLSILLVPGALVL-VILYLCERQCNDLMGAP----PPGPWGLPFLGYLPFLDARAPHKSLQKLAK 78
            :|.:||..|.|.| .:|..|.:.     .:|    ||||..||.:|.|..|......:||.:|::
Human     2 ALLLLLFLGLLGLWGLLCACAQD-----PSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSE 61

  Fly    79 RYGGIFELKMGRVPTVVLSDAALVRDFFR--RDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHAR 141
            |||.:|.:.:||..||||:....|::...  ...:..|.|:.:...|..|.||..:....||.||
Human    62 RYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAAR 126

  Fly   142 RETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIIN 206
            :.|:..|.:||:.|.|...:...|.:...|..:..|           ....||..|..:..||..
Human   127 QFTVRALHSLGVGREPVADKILQELKCLSGQLDGYR-----------GRPFPLALLGWAPSNITF 180

  Fly   207 DLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG--VVNFLPWLRHLPANVRNIRFLLEGKAKTHA 269
            .|:||..:...||.::.|..|.:|.:.|:|..|  :.|..|||
Human   181 ALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWL---------------------- 223

  Fly   270 IYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDT 334
                     |..|:..:.|.::::|.:.:.|.|.:.:.......||.....:|.....:.|
Human   224 ---------GALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGD---- 275

  Fly   335 YEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHEL 399
             :||.:.....||..|              .|:..||.:|:.|||:|..|.:.|....|.|:.|.
Human   276 -DPEGLFAEANAVACT--------------LDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEE 325

  Fly   400 L-LPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSE 461
            | ..|||  :|.||:.:.|.|..|.:.|..|..:::| .:|.....:..:|.:.:..|:.::...
Human   326 LDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLL 389

  Fly   462 WAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRF 526
            .::.:|...:..|.:|.|..||.|:|.:.....|:|||:|.|:|.||.:||..|.|....:|:
Human   390 TSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQ-- 452

  Fly   527 HLELPSGTEVDMAGESG 543
              ..|.|.....||.:|
Human   453 --SSPQGPPAPTAGAAG 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	119/470 (25%)
CYP2W1	XP_011513742.1	cytochrome_P450	63..459	CDD:477761	117/461 (25%)