Protein Alignment phm and cyp2d6

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001015719.1
• Gene: cyp2d6 / 548436
• XenbaseID: XB-GENE-855872
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 531
• Identity: 139/531 - (26%)
• Similarity: 240/531 - (45%)
• Gaps: 79/531 - (14%)

  Fly    16 SVQSLSILLVPGALVLVILYLCERQ--CNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAK 78
            :|.:|.|:.   .|:|::|...:|:  |.|.    ||.|...||:|.|..:|.|..|.|.::|:|
 Frog    15 NVFTLGIIF---TLLLLLLDFMKRRKPCTDF----PPSPPSWPFVGNLLQMDFRDLHNSFKQLSK 72

  Fly    79 RYGGIFELKMGRVPTVVLSDAALVRD-FFRRDVMTGRAPLYLTHGIMGGFG-----IICAQEDIW 137
            :||.:..|::...|||||:...:::: ..::...|...|.:..:.|:|..|     ::......|
 Frog    73 QYGDVMSLRVFWKPTVVLNGFEVIKEALIQKSEDTADRPPFNLYEILGFVGNNKAVVLANYGQSW 137

  Fly   138 RHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLG 202
            :..||.|:..|:..||.::..|.|.|         ||...|.|....:. ....:|...::.::.
 Frog   138 KDLRRFTLSTLRDFGMGKKSLEERVR---------DEAGYLCDAFQSEQ-GGPFDPHVLINTAVS 192

  Fly   203 NIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIG--VSGVVNFLPWLRHLPANVRNIRFLLEGKA 265
            |:|..::||..::.||..:|.|..|.||.:|...  |..:::.|||...:|...|     |..:.
 Frog   193 NVICSIIFGERFEYDDHKFLKLLCLIEESIKAESGPVPQIISSLPWSSKVPGLAR-----LFFQP 252

  Fly   266 KTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESD 330
            :.|.:         |.|:|.....|:..:....:..::...|...|..
 Frog   253 RIHML---------QYLQEIINEHKQTWDSGHTRDFIDAFMLEMKKAK----------------- 291

  Fly   331 EEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRR 395
                           .|:|::   :.|..|....||||.||.:|:..||||.||::......||:
 Frog   292 ---------------GVKDSN---FNDQNLLLTTADLFSAGSETTTTTLRWGLLFMLLYPDVQRK 338

  Fly   396 LHE---LLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMI 457
            :.|   .::.....||:.::..:.|..|.|.|..|...::||.:||....:..:..:||..|::|
 Frog   339 VQEEIDQVIGRTRKPTMGDVLQMPYTNAVIHEIQRYADIIPLSVPHMAYRDTHIKGFFIPKGTVI 403

  Fly   458 VCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRI 522
            :.:..::..|...:.:|.:|.||.||..||.:.....|:.||:|.|:|.||::|||.|.||...:
 Frog   404 MTNLSSVLKDEKVWEKPFQFYPEHFLDRDGKFVKREAFMAFSAGRRVCLGEQLARMELFLFFTSL 468

  Fly   523 LRRFHLELPSG 533
            |:||..::|.|
 Frog   469 LQRFSFQIPDG 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	130/496 (26%)
cyp2d6	NP_001015719.1	p450	52..501	CDD:306555	125/487 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000