DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and Cyp2f4

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_062176.1	Gene:	Cyp2f4 / 54246	RGDID:	2476	Length:	491	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	150/553 - (27%)
Similarity:	234/553 - (42%)	Gaps:	89/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGI 83
            |.:|||    |:|.::.|.....:...|..||||..||.||.|..|.::....||.||:|.||.:
  Rat     5 STAILL----LLLAVISLSLTFTSWGKGQLPPGPKPLPILGNLLQLRSQDLLTSLTKLSKDYGSV 65

  Fly    84 FELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETID 146
            |.:.:|....:|||....|::..  :.:..:||....:......|.||..:..:.|:..||.::.
  Rat    66 FTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGSYPIFFNFTKGNGIAFSDGERWKILRRFSVQ 130

  Fly   147 WLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFG 211
            .|:..||.:|      .:|.||   ::|...|.|. .:|:.....:|:..|..|:.|||..::||
  Rat   131 ILRNFGMGKR------SIEERI---LEEGSFLLDV-LRKTEGKPFDPVFILSRSVSNIICSVIFG 185

  Fly   212 ITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNI-RFLLEGKAKTHAIYDRIV 275
            ..:..||...|.:.....:..:::.       .||     ..:.|| ..||:.....|
  Rat   186 SRFDYDDERLLTIIHFINDNFQIMS-------SPW-----GEMYNIFPSLLDWVPGPH------- 231

  Fly   276 EACGQRLKEKQKVFKELQEQKRL-QRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPEC 339
                      ::||:.....|.| .|.:.:.|                       |..|...|..
  Rat   232 ----------RRVFRNFGGMKDLIARSVREHQ-----------------------DSLDPNSPRD 263

  Fly   340 ILEHFLAVRDTDSQLYCDDQLRHLLAD---------LFGAGVDTSLATLRWFLLYLAREQRCQRR 395
            .::.||.....:.|    |.|.|...|         ||| |.:|...|||...|.|.:..:.|.|
  Rat   264 FIDCFLTKMVQEKQ----DPLSHFNMDTLLMTTHNLLFG-GTETVGTTLRHAFLILMKYPKVQAR 323

  Fly   396 LHELL-LPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMI 457
            :.|.: ..:|.|  ||||:...:.|..|.|.|..|...|:|:.:||....:.....:.|..|:.:
  Rat   324 VQEEIDCVVGRSRMPTLEDRASMPYTDAVIHEVQRFADVIPMNLPHRVIRDTPFRGFLIPKGTDV 388

  Fly   458 VCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRI 522
            :.....:|.|...|..|:||.||.||.|:.:::..|.|:|||:|.|:|.||.:|||.|.::...|
  Rat   389 ITLLNTVHYDSDQFKTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGEPLARMELFIYLTSI 453

  Fly   523 LRRFHLE-LPSGTEVDMAG-ESGITLTPTPHML 553
            |:.|.|. |....::|:.. .||:...|.|..|
  Rat   454 LQNFTLHPLVEPEDIDLTPLSSGLGNLPRPFQL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	142/523 (27%)
Cyp2f4	NP_062176.1	p450	31..488	CDD:278495	142/523 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000