DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2c24

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001258283.1	Gene:	Cyp2c24 / 499353	RGDID:	1563697	Length:	490	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	142/556 - (25%)
Similarity:	238/556 - (42%)	Gaps:	96/556 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIF 84
            |.::|....|:|:.|:   ||.:. .|..||||..||.:|.:..:|.:...||....:|.||.:|
  Rat     5 LVLVLTLSCLLLLSLW---RQSSG-RGKLPPGPTPLPIIGNILQIDVKDISKSFTNFSKIYGPVF 65

  Fly    85 ELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDW 147
            .|..|..||||:.....|::..  ..:..:||....:...:..|.|:|.:....|:..|..::..
  Rat    66 TLYFGPKPTVVVHGYEAVKEALDDLGEEFSGRGSFPIVERMNNGLGVIFSNGTKWKELRHFSLMT 130

  Fly   148 LKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGI 212
            |:..||.:|      .:|.||.   :|...|.: |.:|:..|..:|...|..:..|:|..:||..
  Rat   131 LRNFGMGKR------SIEDRIQ---EEASCLVE-ELRKTNGSLCDPTFILSCAPSNVICSVVFHN 185

  Fly   213 TYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLR---HLPANVRNIRFLLEGKAKTHAIYDRI 274
            .:...|.::|.|.....|..|::.       .||::   .|||.:.    .|.|.      ::|:
  Rat   186 RFDYKDENFLNLMEKLNENFKILN-------SPWMQVCNALPAFID----YLPGS------HNRV 233

  Fly   275 VEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESD------EED 333
            :           |.|.|::..          .||:.||   .||..:.|...:..|      |::
  Rat   234 I-----------KNFAEIKSY----------ILRRVKE---HQETLDMDNPRDFIDCFLIKMEQE 274

  Fly   334 TYEP--ECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRL 396
            .:.|  |..:|..:|.                ::|:|.||.:|:..|||:.||.|.:......::
  Rat   275 KHNPRTEFTIESLMAT----------------VSDVFVAGSETTSTTLRYGLLLLLKHTEVTAKV 323

  Fly   397 HELL---LPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIV 458
            .|.:   :.....|.:::...:.|..|.:.|..|..:::|..:||....|....:|.|..|:.:|
  Rat   324 QEEIDHVIGRHRRPCMQDRTRMPYTDAMVHEIQRYINLIPNNVPHAATCNVRFRNYVIPKGTDLV 388

  Fly   459 CSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRIL 523
            .|..::..|...||.||.|.|..||..:|.::....|:|||:|.|||.||.:|||.|.|....|:
  Rat   389 TSLTSVLHDDKEFPNPEVFDPGHFLDENGNFKKSDYFMPFSTGKRMCVGEALARMELFLLLTTIV 453

  Fly   524 RRFHLELPSGTEVDMAGESGITLTPTPHMLRFTKLP 559
            :.|:|:....|:         .:..||....|.::|
  Rat   454 QNFNLKSFVDTK---------DIDTTPMANTFGRVP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	132/521 (25%)
Cyp2c24	NP_001258283.1	p450	30..487	CDD:278495	134/527 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000