DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and cyp2v1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001009890.1	Gene:	cyp2v1 / 494153	ZFINID:	ZDB-GENE-040912-139	Length:	504	Species:	Danio rerio

Alignment Length:	541	Identity:	146/541 - (26%)
Similarity:	239/541 - (44%)	Gaps:	73/541 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVLVILYLCE----RQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMG 89
            |:|.||:|..    |..|......||||..|||:|.:..||...||..|.|::..||.||.|::|
Zfish    22 LLLFILFLLVSVKLRNRNKPHKNLPPGPTPLPFIGNVFNLDTSQPHIDLTKMSDHYGNIFSLRLG 86

  Fly    90 RVPTVVLSDAALVRDFFRRDVMTGRAPLY-----LTHGIMGGFGIICAQEDIWRHARRETIDWLK 149
            .:.|||::..::|:......   |.:.:|     :|..|....|:.......|:..||.|:..||
Zfish    87 SLNTVVVNTYSMVKKVLNDQ---GNSFMYRPVNDITERISKCQGLTFNNGYSWKQHRRFTLSTLK 148

  Fly   150 ALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITY 214
            ..|:.:|..|.....|.:...     ..:.||.     ....||...:::.:.|||..:|||..:
Zfish   149 FFGVGKRSLEFIIMEEYKFLH-----QSIMDTN-----GLPFNPHYIINNGVSNIICSMVFGRRF 203

  Fly   215 KRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACG 279
            :..|..:|.:..|..:.:||                    :...|:     :.:|.:.|:::...
Zfish   204 EYTDQRFLNMLSLISKALKL--------------------QTSVFI-----QLYAAFPRLMDLLP 243

  Fly   280 QRLKEKQKVFKELQEQKRLQRQLEKEQL-RQSKEADPSQEQSEADEDDEESDEEDTYEPECILEH 343
            ...||....|.::       |...||:: :...:.|||..:...|               |.|..
Zfish   244 GPHKELFSCFHQV-------RAFIKEEVDKHRADWDPSSPRDFID---------------CYLTE 286

  Fly   344 FLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLH-ELLLPLG--P 405
            ....:|.....:.|:.|::.:.|||.||.:|:..||.|..:|:.:....|.::. |:...:|  .
Zfish   287 IEKKKDDLEAGFHDEGLQYAVLDLFVAGTETTSTTLLWAFVYMMKYPEIQEKVQAEIDKVVGRYR 351

  Fly   406 SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVA 470
            .|::::...:.|..|.|.|..|:.:||||.:|....|:.::..|||..|:.|:.:..::..|...
Zfish   352 RPSMDDRPCMPYTDAVIHEIQRMGNVVPLSVPRMTNEDTILEGYFIPKGTQIIPNLTSVLFDQTK 416

  Fly   471 FPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTE 535
            :.....|.|:.||.|.|.::.|..|||||.|.|.||||.:|||.|.||....|:.|.|..|..|:
Zfish   417 WKTQHSFDPQNFLNAQGKFEKPEAFIPFSLGKRSCPGESLARMELFLFFTSFLQSFSLSAPDETQ 481

  Fly   536 VDMAGESGITLTPTPHMLRFT 556
            ..:..:.|:||:|.|..:.||
Zfish   482 TSLDFKFGMTLSPKPFKICFT 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	137/514 (27%)
cyp2v1	NP_001009890.1	p450	46..501	CDD:278495	137/514 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910