DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and cyp2aa4

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_017209028.1	Gene:	cyp2aa4 / 415182	ZFINID:	ZDB-GENE-040625-72	Length:	505	Species:	Danio rerio

Alignment Length:	566	Identity:	147/566 - (25%)
Similarity:	251/566 - (44%)	Gaps:	87/566 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VQSLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYG 81
            :.|:.:.|:.|.::||:..:.  :.:......||||..|||:|.||.| .|.| ....:|..:||
Zfish    10 LSSVGLTLLLGLILLVLFEIF--RIHSYKSRFPPGPTPLPFVGNLPHL-LRDP-MGFNRLMAQYG 70

  Fly    82 GIFELKMGRVPTVVLSDAALVRDFFRRDVMTGRAPLYLTHGIMGGFGIICAQ-EDIWRHARRETI 145
            .:..:.:|:.|.:||:...:.::...::...||..|.:......|.|||.|. .:.|:..||..:
Zfish    71 EMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPVIDWTSNGCGIIMATFNNSWKQQRRFAL 135

  Fly   146 DWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVF 210
            ..|:..|:.::      .:|.|:   ::|...|| .|..|.....|||..||.:::.||...::|
Zfish   136 HTLRNFGLGKK------SIESRV---LEESQYLF-AELLKDEGEPVNPHHALQNAVSNIFCSIMF 190

  Fly   211 GITYKRDDPDWLYLQRLQEEGVKLIG--VSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDR 273
            |..:..|:....||.::..|.:.|.|  :..:.|..|:::|.|...:.|      |..::.:|..
Zfish   191 GERFDYDNKRLGYLLKILNENMMLTGSAIGQIFNLAPFIKHFPGPHQKI------KKNSNELYSF 249

  Fly   274 IVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADE-----DDEESDEED 333
            |.:              |::|.:              |..||...:...|.     :.::|:::.
Zfish   250 IED--------------EVEEHR--------------KTLDPVSPRDFIDAYLLEIEKQKSNKDS 286

  Fly   334 TYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLH- 397
            |::.|.::...:                    |||.||.|::..::||.||:|.:....|.|.|
Zfish   287 TFQEENLIGSAI--------------------DLFFAGTDSTATSIRWGLLFLIQNPDVQERCHE 331

  Fly   398 ELLLPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCS 460
            |::..||..  |.:::.:.|.|..|.:.|..|....||.|:.|.......:..:.|..|:||:.:
Zfish   332 EIVQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFGVFHETIWPTKLHGFDIPQGTMIMTN 396

  Fly   461 EWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRR 525
            ..||......:..|:.|.||.||..:|.:..|..:||||.|.|.|.||.:|:..|.||...:|:|
Zfish   397 LAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESYIPFSLGPRSCLGETLAKTELFLFITSLLQR 461

  Fly   526 FHLE-LPSGTEVDMAGESGITLTPTPHML----RFTKLPAVEMRHA 566
            .... ||....:||.|..||...|.|..:    |.||   .:::||
Zfish   462 IRFSWLPDAKPLDMDGIMGIVRYPQPFSIICCSRDTK---SDLKHA 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	137/521 (26%)
cyp2aa4	XP_017209028.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910