DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and cyp2k22

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_956529.1	Gene:	cyp2k22 / 393204	ZFINID:	ZDB-GENE-040426-822	Length:	503	Species:	Danio rerio

Alignment Length:	564	Identity:	154/564 - (27%)
Similarity:	248/564 - (43%)	Gaps:	107/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LVPG---------ALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKR 79
            |:||         |.:|:.|.:.....:...|..||||..||.||.|..||.:..:.||.||:|:
Zfish     7 LLPGLSFTVGMVVAFLLLFLVISYFSSSKDQGKYPPGPKPLPLLGNLHILDLKNTYMSLWKLSKQ 71

  Fly    80 YGGIFELKMGRVPTVVLSDAALVR--------DFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDI 136
            ||.::.:.||....||||....|:        :|..||:    :|::  .....|:||:.:..:.
Zfish    72 YGPVYTVHMGPRTVVVLSGYKAVKEALVNLSEEFGERDI----SPIF--QDFNEGYGIVFSNGEN 130

  Fly   137 WRHARRETIDWLKALGMTRRPGE---------LRARLERRIARGVDECVRLFDTEAKKSCASEVN 192
            |:..||..:..|:..||.::.||         |:..:||...:.       |:|:
Zfish   131 WKEMRRFALSNLRDFGMGKKRGEELITEEIKYLKEEIERFGGKP-------FETK---------- 178

  Fly   193 PLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGV--VNFLPWLRHLPANVR 255
             || |..::.|:|..:|:.|.::.:.|.:........|..||:|...|  .|..||||
Zfish   179 -LP-LAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQLYNMFPWLR------- 234

  Fly   256 NIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQE-QKRLQRQLEKEQLRQSKEADPSQEQ 319
              .|::..|        |:|:       ..|:.||::.| ...|::.|..:..|...:....|:|
Zfish   235 --LFVINQK--------RVVD-------NVQESFKQIGEIVNGLKKTLNPQSPRGIADKFLIQQQ 282

  Fly   320 SEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLL 384
            .     |:||.:.|:                   ||..:.....:.:|||||:||::.||||.||
Zfish   283 K-----DKESGKTDS-------------------LYNSNNFLTTINNLFGAGIDTTVTTLRWGLL 323

  Fly   385 YLAREQRCQRRLH-ELLLPLGP-SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVG 447
            .:|:....|.::| |:...:|. .|...:.:.|.|..|.|.|..|...::|:|:......:..:.
Zfish   324 LIAKYPEIQAKVHDEIDSVIGERQPVPGDRKNLPYTDAVIHEIQRFADILPIGLLRQTSCDVHLN 388

  Fly   448 DYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMAR 512
            .|.||.|:.:.....::..|...:..|:.|.|:.||...|.:.....|:||.:|.|:|.||.:||
Zfish   389 GYLIKKGTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLAR 453

  Fly   513 MILTLFTGRILRRFHLELPSGT---EVDMAGESGITLTPTPHML 553
            |.|.||...:|:.|....|.|.   |:|:....|.||:|.||.|
Zfish   454 MELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	147/530 (28%)
cyp2k22	NP_956529.1	p450	62..498	CDD:278495	136/509 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910