Protein Alignment phtm and Cyp2d12

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_958748.1
• Gene: Cyp2d12 / 380997
• MGIID: 88604
• Length: 504
• Species: Mus musculus
• Alignment Length: 554
• Identity: 148/554 - (26%)
• Similarity: 231/554 - (41%)
• Gaps: 90/554 - (16%)

  Fly    21 SILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFE 85
            |:.:.....:|::..:..||  ......||||...|.||.|..:|......||.||..|||.:|.
Mouse    11 SVAIFTVIFILLVDLMHRRQ--SWTSCYPPGPVPWPVLGNLLQVDLNNMPYSLYKLQNRYGDVFS 73

  Fly    86 LKMGRVPTVVLSDAALVRDFFRR--DVMTGRAPLYLTHGIMGGF-----GIICA-QEDIWRHARR 142
            |:|...|.||::....:::....  :....|.|:.:...:  ||     |:|.| ....||..||
Mouse    74 LQMAWKPMVVINRMKAMKEVLLTCGEDTADRPPVPIFEHL--GFKPRSQGMIFAPYGPEWREQRR 136

  Fly   143 ETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIIND 207
            .::..|:..|:.|:      .||..:.:........|.|:|    ...:||...|..:..|:|..
Mouse   137 FSLSSLRNFGLGRK------SLEEWVIKEAGHLCDAFTTQA----GQYINPNTMLKKATCNVIAS 191

  Fly   208 LVFGITYKRDDPDWLYLQR----LQEEGVKLIG-VSGVVNFLPWLRHLPANVRNIRFLLEGKAKT 267
            |:|...::.:||   ||.|    |::...:|.| :..|:|..|.|.|:|
Mouse   192 LIFARRFEYEDP---YLIRMLKVLEDSLTELSGLIPEVINTFPILLHIP---------------- 237

  Fly   268 HAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEE 332
                         ||.:     |.||.||.....::..........||:|
Mouse   238 -------------RLAD-----KFLQSQKSFIAIVDNLLTENRTTWDPAQ--------------- 269

  Fly   333 DTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQ 393
               .|..:.:.|||    .:......:.|:.||.::.|||.||:.|:..||.|.||.:......|
Mouse   270 ---SPRNLTDAFLAEIEKAKGNPESSFNDENLRMVVIDLFTAGILTTSTTLSWALLLMILHPDVQ 331

  Fly   394 RRL-HELLLPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGS 455
            ||: .|:...:|.  .|.:.:...:.|..|.|.|..|...:|||.:|.....:..|.|:.|..|:
Mouse   332 RRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPLHLPRITSRDIEVQDFLIPKGT 396

  Fly   456 MIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTG 520
            :::.:..::|||...:.:|..|.||.||.|.|.:.....||.||:|.|.|.||.:|||.|.||..
Mouse   397 ILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHFVKHEAFITFSAGRRSCLGEPLARMELFLFFT 461

  Fly   521 RILRRFHLELPSG-TEVDMAGESGITLTPTPHML 553
            .:|:||...:|.| .:........|.:.|:|:.|
Mouse   462 CLLQRFSFSVPDGQPQPSDHRVFSIMVAPSPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	128/492 (26%)
Cyp2d12	NP_958748.1	CYP2D	68..495	CDD:410756	129/493 (26%)