Protein Alignment phm and Cyp2d12

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_958748.1
• Gene: Cyp2d12 / 380997
• MGIID: 88604
• Length: 504
• Species: Mus musculus
• Alignment Length: 554
• Identity: 148/554 - (26%)
• Similarity: 231/554 - (41%)
• Gaps: 90/554 - (16%)

  Fly    21 SILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFE 85
            |:.:.....:|::..:..||  ......||||...|.||.|..:|......||.||..|||.:|.
Mouse    11 SVAIFTVIFILLVDLMHRRQ--SWTSCYPPGPVPWPVLGNLLQVDLNNMPYSLYKLQNRYGDVFS 73

  Fly    86 LKMGRVPTVVLSDAALVRDFFRR--DVMTGRAPLYLTHGIMGGF-----GIICA-QEDIWRHARR 142
            |:|...|.||::....:::....  :....|.|:.:...:  ||     |:|.| ....||..||
Mouse    74 LQMAWKPMVVINRMKAMKEVLLTCGEDTADRPPVPIFEHL--GFKPRSQGMIFAPYGPEWREQRR 136

  Fly   143 ETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIIND 207
            .::..|:..|:.|:      .||..:.:........|.|:|    ...:||...|..:..|:|..
Mouse   137 FSLSSLRNFGLGRK------SLEEWVIKEAGHLCDAFTTQA----GQYINPNTMLKKATCNVIAS 191

  Fly   208 LVFGITYKRDDPDWLYLQR----LQEEGVKLIG-VSGVVNFLPWLRHLPANVRNIRFLLEGKAKT 267
            |:|...::.:||   ||.|    |::...:|.| :..|:|..|.|.|:|
Mouse   192 LIFARRFEYEDP---YLIRMLKVLEDSLTELSGLIPEVINTFPILLHIP---------------- 237

  Fly   268 HAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEE 332
                         ||.:     |.||.||.....::..........||:|
Mouse   238 -------------RLAD-----KFLQSQKSFIAIVDNLLTENRTTWDPAQ--------------- 269

  Fly   333 DTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQ 393
               .|..:.:.|||    .:......:.|:.||.::.|||.||:.|:..||.|.||.:......|
Mouse   270 ---SPRNLTDAFLAEIEKAKGNPESSFNDENLRMVVIDLFTAGILTTSTTLSWALLLMILHPDVQ 331

  Fly   394 RRL-HELLLPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGS 455
            ||: .|:...:|.  .|.:.:...:.|..|.|.|..|...:|||.:|.....:..|.|:.|..|:
Mouse   332 RRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPLHLPRITSRDIEVQDFLIPKGT 396

  Fly   456 MIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTG 520
            :::.:..::|||...:.:|..|.||.||.|.|.:.....||.||:|.|.|.||.:|||.|.||..
Mouse   397 ILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHFVKHEAFITFSAGRRSCLGEPLARMELFLFFT 461

  Fly   521 RILRRFHLELPSG-TEVDMAGESGITLTPTPHML 553
            .:|:||...:|.| .:........|.:.|:|:.|
Mouse   462 CLLQRFSFSVPDGQPQPSDHRVFSIMVAPSPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	144/526 (27%)
Cyp2d12	NP_958748.1	p450	37..496	CDD:278495	144/526 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000