Protein Alignment phtm and Cyp2r1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001388556.1
• Gene: Cyp2r1 / 361631
• RGDID: 1311866
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 150/565 - (26%)
• Similarity: 254/565 - (44%)
• Gaps: 97/565 - (17%)

  Fly    14 MPSVQSLSILLVPGALVLVILYLCERQCNDLM-----GAPPPGPWGLPFLGYL--PFLDARAPHK 71
            :|.||:.:..|. ||.:|::|.|..||   |:     ...||||..|||:|.:  ..|.|..||.
  Rat     4 LPGVQTCAGALA-GAFLLLLLVLVVRQ---LLRQRRPAGFPPGPPRLPFIGNICSLALSADLPHV 64

  Fly    72 SLQKLAKRYGGIFELKMGRVPTVVLSDAALVRD--FFRRDVMTGR--APLYLTHGIMGGF----- 127
            .::|.::.:|.||.|.:|.:.||||:...:|::  ..:.::...|  .||::....|||.
  Rat    65 YMRKQSRVFGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRY 129

  Fly   128 --GIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDT-EAKKSCAS 189
              |        |...||..::.....|..::..|         ::.::|...|.|. |..|....
  Rat   130 GRG--------WIDHRRLAVNSFHYFGSGQKSFE---------SKILEETWSLIDAIETYKGRPF 177

  Fly   190 EVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGV--VNFLPWLRHLPA 252
            ::..|  :.:::.||.|.::||..:..:|.|:.::..|..|.|:|...:.|  .|..||:..||.
  Rat   178 DLKQL--ITNAVSNITNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNAFPWIGILPF 240

  Fly   253 NVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQ 317
                      ||   |           |||.....|..:.     |.:.:||..:.:......:.
  Rat   241 ----------GK---H-----------QRLFRNADVVYDF-----LSKLIEKAAVNRKPHLPQNF 276

  Fly   318 EQSEADEDDE-ESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRW 381
            ..:..||.|: ::|...|:..|                    .|...:.:|..||.:|:...|||
  Rat   277 VDAYLDEMDKGQNDPLSTFSKE--------------------NLIFSVGELIIAGTETTTNVLRW 321

  Fly   382 FLLYLAREQRCQRRLH---ELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKEN 443
            .:|::|.....|.::|   :|::.....|:.|:...:.|..|.:.|.:|..::|||||.|...|:
  Rat   322 AVLFMALYPNIQGQVHKEIDLIMGHDRRPSWEDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSED 386

  Fly   444 FVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGE 508
            .||..|.|..|:.::.:.:::|.|...:.:|:.|.|||||.:.|.:......||||.|.|.|.||
  Rat   387 AVVRGYSIPKGTTVITNLYSVHFDEKYWKDPDMFYPERFLDSSGYFTKKEALIPFSLGRRHCLGE 451

  Fly   509 EMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITLTPTPHML 553
            ::|||.:.||...:|::|||..|.....::....|:||.|..:::
  Rat   452 QLARMEMFLFFTSLLQQFHLHFPHELVPNLKPRLGMTLQPQAYLI 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	125/489 (26%)
Cyp2r1	NP_001388556.1	cytochrome_P450	62..497	CDD:477761	128/503 (25%)