Protein Alignment phtm and CYP27C1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 137/571 - (23%)
• Similarity: 218/571 - (38%)
• Gaps: 150/571 - (26%)

  Fly    46 GAPP--------------PGPWGLPFLGYLPFLDARAP-HKSLQKLAKRYGGIFELKMGRVPTVV 95
            |:||              |||..|..|......|..:. |:..||..:.||.||:...|....|.
Human    52 GSPPGGGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVVS 116

  Fly    96 LSDAALVRDFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHAR-----------RETIDWLK 149
            ::|..:|....|.:   |.||..             |..:.||..|           .|...|||
Human   117 IADRDMVAQVLRAE---GAAPQR-------------ANMESWREYRDLRGRATGLISAEGEQWLK 165

  Fly   150 ALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITY 214
                      :|:.|.:||.:..|..:          .:.|||          .:|.||:
Human   166 ----------MRSVLRQRILKPKDVAI----------YSGEVN----------QVIADLI----- 195

  Fly   215 KRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNI--RFLLEGKAKTHAIYD----- 272
            ||     :||.|.|.|..:.:                .||.::  ::.:||.|.  .:|:
Human   196 KR-----IYLLRSQAEDGETV----------------TNVNDLFFKYSMEGVAT--ILYESRLGC 237

  Fly   273 ----------RIVEACGQRLKEKQKVFKELQEQKRLQRQLE----KEQLRQSKEADPSQEQSEAD 323
                      ..:||    |:....:||.......:.|.|.    |......:..|...:.|:..
Human   238 LENSIPQLTVEYIEA----LELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIH 298

  Fly   324 EDDEESDEEDTYEPE--------CILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLR 380
            .|::..|.:  |:.:        .:...||:...|..::|.:      :.::..|||||:..||.
Human   299 VDNKLRDIQ--YQMDRGRRVSGGLLTYLFLSQALTLQEIYAN------VTEMLLAGVDTTSFTLS 355

  Fly   381 WFLLYLAREQRCQRRLH-ELLLPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKE 442
            |.:..|||....|:.:: |::..||..  ||..::..:..:||.:.||:|:..|:| |.....:|
Human   356 WTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLP-GNGRVTQE 419

  Fly   443 NFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQF--IPFSSGYRMC 505
            :.|:|.|.|..|:.:....:|.......||..:||||||:| ..|.......|  |||..|.|.|
Human   420 DLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWL-RKGDLDRVDNFGSIPFGHGVRSC 483

  Fly   506 PGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITLTP-TPHMLRF 555
            .|..:|.:.:.|...::|:.|.::..|.|....|...|: ||| .|..:||
Human   484 IGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGL-LTPGGPIHVRF 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	122/517 (24%)
CYP27C1	NP_001354431.1	CYP27C1	98..530	CDD:410740	123/520 (24%)