DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and cyp2x12

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_005166578.1	Gene:	cyp2x12 / 325939	ZFINID:	ZDB-GENE-030131-4664	Length:	496	Species:	Danio rerio

Alignment Length:	574	Identity:	155/574 - (27%)
Similarity:	239/574 - (41%)	Gaps:	124/574 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFEL 86
            :||..||. |:.|.:..|:..|.    ||||..:||.|.|..|:...|.|.|.|.|:.||.|:.:
Zfish     6 VLLCLGAF-LLYLQVRIRRPKDF----PPGPAPVPFFGNLLQLNRINPIKDLDKFAQHYGSIYGI 65

  Fly    87 KMGRVPTVVLSDAALVRD--FFRRDVMTGRAPLYLTHGIMGGFGIICAQ-EDIWRHARRETIDWL 148
            .:|..|.|||:...::::  ..:.....||....:...|....|:|.|. .:.||..||..:..|
Zfish    66 YIGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMMISHITRSKGVIMADYGESWREHRRFALTTL 130

  Fly   149 KALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGIT 213
            :..|:.::      .:|:||...|.....|.:..|.||    ::|....|.:..|||..::||..
Zfish   131 RNFGLGKK------SMEQRILEEVKHICLLLEESAGKS----IDPQHLYHQAASNIIASVIFGSR 185

  Fly   214 YKRDDPDWLYLQRLQEEGVKL----IGVSGVV-NFLPWLRHLPANVRNIRFLLEGKAKTHAIYDR 273
            :...|.   |.|.|.:...||    ||...:: ...|.||..|..........| |...|::  :
Zfish   186 FNYKDE---YFQTLIQTMEKLTKIAIGTWAMLYEIAPVLRIFPLPFWKAFHYFE-KITRHSL--K 244

  Fly   274 IVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPE 338
            :||       |.:|.|...:.:..:...||:.:.|                    :|:..|::
Zfish   245 VVE-------EHKKSFVAGEPKDLIDCYLEEMKKR--------------------ADQRTTFD-- 280

  Fly   339 CILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAR----EQRCQRRLHEL 399
                              :.|:..||.|||.||.:|:..|||...|||..    :::|||.:.|:
Zfish   281 ------------------EAQMVTLLFDLFLAGTETTSNTLRTLTLYLMTHTHIQEQCQREIDEV 327

  Fly   400 LLPLGPSP--TLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVC--- 459
               ||...  |.|:...:.:::|.|.|..|:..:|||.:.|..:.:..:..|.|..|::|:.
Zfish   328 ---LGARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTARTDTQLRGYSIPKGTIIIPYLS 389

  Fly   460 ------SEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLF 518
                  |:|..         |.||.|:.||...|.:.....|:|||:|.|:|.||.:|||.|.|.
Zfish   390 SSLREESQWKF---------PHEFNPQNFLNEKGEFVKNEAFMPFSAGPRVCLGENLARMELFLI 445

  Fly   519 TGRILRRFHLELPSGTEVDMAGESGIT--------LTPTPHMLRFTKLPAVEMR 564
            ...:||:|.|..|..     |||...|        |.|.|.:        ||:|
Zfish   446 LVTVLRKFRLVWPKD-----AGEPDFTYIYGGTQSLKPYPMI--------VELR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	144/536 (27%)
cyp2x12	XP_005166578.1	p450	28..466	CDD:278495	140/517 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000