DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and cyp2x10.2

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001315444.1	Gene:	cyp2x10.2 / 322545	ZFINID:	ZDB-GENE-060818-12	Length:	496	Species:	Danio rerio

Alignment Length:	556	Identity:	147/556 - (26%)
Similarity:	230/556 - (41%)	Gaps:	126/556 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFEL 86
            :||..||.:|.:.....|..|.     ||||..:|..|.|..|:..:|.|...|.|:.||.|:.:
Zfish     6 VLLCLGAFLLYLQLRIRRPKNF-----PPGPAPVPIFGNLLQLNRISPLKDFDKFAQHYGSIYGI 65

  Fly    87 KMGRVPTVVLSDAALVRD--FFRRDVMTGRAPLYLTHGIMGGFGIICAQ-EDIWRHARRETIDWL 148
            .:|..|.|||:...::::  ..:....:||:...:...:.||.|:|.|. .:.||..||..:..|
Zfish    66 YIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGKGVIMADYGESWREHRRFALTTL 130

  Fly   149 KALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGIT 213
            :..|:.::      .:|:||...|.....|.:..|.||    ::|....|.:..|||..::||..
Zfish   131 RNFGLGKK------SMEQRILEEVKHICLLLEESAGKS----IDPQHLYHQAASNIIASVIFGSR 185

  Fly   214 YKRDDPDWLYLQRL---QEEGVKL-IGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRI 274
            :...|   .|.|.|   .|:..|: ||        ||.                     .:|:
Zfish   186 FNYKD---AYFQTLITSVEDLTKITIG--------PWA---------------------MLYE-- 216

  Fly   275 VEACGQRLKEKQKVFKELQEQKRLQ--RQLEKEQLRQSKEADPSQEQSE--------ADEDDEES 329
                   :....::| .|..||..|  .|:.|..|:..:|...|:...|        .:|.:.:|
Zfish   217 -------IAPVLRIF-PLPFQKAFQYFEQITKHVLKVVEEHKTSRVAGEPRDLIDCYLEEMENKS 273

  Fly   330 DEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAR----EQ 390
            |...:::                    :.|:..||.|||.||.:|:..|||...|||..    ::
Zfish   274 DHRTSFD--------------------ESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQE 318

  Fly   391 RCQRRLHELLLPLGPSP--TLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKG 453
            :|||.:.|:   ||...  |.|:...:.:::|.|.|..|:..:.||.:.|..|.:..:..|.|..
Zfish   319 QCQREIDEV---LGARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTDTQLRGYSIPK 380

  Fly   454 GSMIVC---------SEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEE 509
            |::|:.         .:|..         |.||.|:.||...|.:.....|:|||:|.|:|.||.
Zfish   381 GTIIIPYLSSSLREEGQWKF---------PHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGEN 436

  Fly   510 MARMILTLFTGRILRRFHLELPSGTEVDMAGESGIT 545
            :|||.|.|....:||||.|..|..     |||...|
Zfish   437 LARMELFLILVTVLRRFRLVWPKD-----AGEPDFT 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	140/529 (26%)
cyp2x10.2	NP_001315444.1	p450	28..483	CDD:278495	140/529 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000