DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2u1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001380742.1	Gene:	Cyp2u1 / 310848	RGDID:	1309433	Length:	530	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	160/576 - (27%)
Similarity:	257/576 - (44%)	Gaps:	98/576 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PSVQSL-SILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFL-------------- 64
            |.:|:: ..||:.|..||:.....:||   ..|..||||...|.:|...:|
  Rat    19 PHLQAVGGALLLCGLAVLLDWVWLQRQ---RAGGIPPGPKPRPLVGNFGYLLLPRFLRLHFWLGS 80

  Fly    65 ----DARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGI 123
                |....|..|.:||:.||.||...:|....|||||...||:..  :.:|.:.|..:.|...:
  Rat    81 GSQTDTVGRHVYLARLARVYGNIFSFFIGHRLVVVLSDFQSVREALVQQAEVFSDRPRMPLISIL 145

  Fly   124 MGGFGIICAQ-EDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSC 187
            ....||:.|. ..||:..||.:...|:..|:    |:|  .||.||   ::|...: ..|.:|..
  Rat   146 TKEKGIVFAHYGPIWKQQRRFSHSTLRHFGL----GKL--SLEPRI---IEEFAYV-KAEMQKHG 200

  Fly   188 ASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG--VVNFLPWLRHL 250
            .:..:|.|.:.:::.|||..|.||..:...:.::..:......|:::...|.  ::|..||..:|
  Rat   201 EAPFSPFPVISNAVSNIICSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQLFLINLCPWFYYL 265

  Fly   251 PANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEA-D 314
            |..                                  .||||::.:|......|..:::.:|: |
  Rat   266 PFG----------------------------------PFKELRQIERDITCFLKNIIKEHQESLD 296

  Fly   315 PSQEQSEAD----EDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTS 375
            .:..|...|    ...||.|       :|        :.|:   :.:|.|.:::.|||.||.||:
  Rat   297 ANNPQDFIDMYLLHTQEEKD-------KC--------KGTN---FDEDYLFYIIGDLFIAGTDTT 343

  Fly   376 LATLRWFLLYLAREQRCQRRLH---ELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIP 437
            ..:|.|.|||::.....|:::|   |.::....:|:|.:...:.|..|.|.|..|:..||||.||
  Rat   344 TNSLLWCLLYMSLNPGVQKKVHEEIERVIGRDRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIP 408

  Fly   438 HGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGY 502
            |...|..|:..|.|..|::::.:.|:||.|||.:.:|::|.|.|||...|.......||||..|.
  Rat   409 HMTSEKTVLQGYSIPKGTVVLPNLWSIHRDPVIWEKPDDFCPHRFLDDQGQLLKRETFIPFGIGK 473

  Fly   503 RMCPGEEMARMILTLFTGRILRRFHLELPSGTEVD-MAGESGITLTPTPHMLRFTK 557
            |:|.||::|:|.|.|....:::.|...||.|:|.. |.|..|:||.|.|..:..:|
  Rat   474 RVCMGEQLAKMELFLMFVSLMQSFTFALPEGSEKPIMTGRFGLTLAPHPFNVTVSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	149/537 (28%)
Cyp2u1	NP_001380742.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24300
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010