DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001100965.1	Gene:	Cyp2s1 / 308445	RGDID:	1306078	Length:	499	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	148/551 - (26%)
Similarity:	231/551 - (41%)	Gaps:	119/551 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MPSVQSLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAK 78
            |.:..:.::||   ||:|::|.|...: ....|..||||..||.||.|..|...|.:....:|:|
  Rat     1 MEAASTWALLL---ALLLLLLALTLPR-TPARGQLPPGPTPLPLLGNLLQLRPGALYSGFLRLSK 61

  Fly    79 RYGGIFELKMG---RVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWR 138
            :||.:|.:.:|   ||..:|..||  :|:..  :.:..:||..|........|.|:..|..:.|:
  Rat    62 KYGPVFTVHLGPWRRVVVLVGHDA--IREALGGQAEEFSGRGTLATLDKTFDGHGVFFANGERWK 124

  Fly   139 HARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFD-TEAKKSCASEVNPLPALHHSLG 202
            ..|:.|:..|:.|||.:|.|      |..|...|...|:.|. ||.:     ..||...|..:..
  Rat   125 QLRKFTLLALRDLGMGKREG------EELIQEEVQNLVKAFQRTEGR-----PFNPSMLLAQATS 178

  Fly   203 NIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPW----------LRHLPANVRNI 257
            |::..|:|||....:|.::..:  :|.....|:|:|.     ||          |:.||.....:
  Rat   179 NVVCSLIFGIRLPYEDKEFQAV--IQAASGTLLGISS-----PWGQAYEMFSWLLQPLPGPHTQL 236

  Fly   258 RFLL--------------EGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLR 308
            :..|              :|::.|......:|:|..|::.:                  |||
  Rat   237 QHHLGTLAAFTIQQVQRHQGRSHTSGPARDVVDAFLQKMAQ------------------EKE--- 280

  Fly   309 QSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVD 373
                 ||..|                                    :.:..|...:..|..||..
  Rat   281 -----DPGTE------------------------------------FTEKNLLMTVTYLLFAGTM 304

  Fly   374 TSLATLRWFLLYLAREQRCQRRL-HELLLPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLG 435
            |..||:|:.||.|.:..:.|:|: .||:..||||  |:|.:...|.|..|.:.|..|:.::||:|
  Rat   305 TIGATIRYALLLLLKYPQVQKRVREELIQELGPSRTPSLSDRVRLPYTDAVLHEAQRLLALVPMG 369

  Fly   436 IPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSS 500
            :||...:......|.:..|:.:.....::..||..|..||||.|.|||..||..:....|:|:|.
  Rat   370 MPHTVTKTTSFRGYTLPKGTEVFPLIGSVLHDPAVFRNPEEFHPSRFLDDDGRIRKHEAFLPYSL 434

  Fly   501 GYRMCPGEEMARMILTLFTGRILRRFHLELP 531
            |.|:|.||.:||..|.||...||:.|.|:.|
  Rat   435 GKRVCLGEGLARAELWLFFTSILQAFSLDTP 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	139/516 (27%)
Cyp2s1	NP_001100965.1	p450	48..491	CDD:365848	129/500 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000