Protein Alignment phm and CYP2S1

DIOPT Version :9

• Sequence 1: NP_001285414.1
• Gene: phm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_085125.1
• Gene: CYP2S1 / 29785
• HGNCID: 15654
• Length: 504
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 155/567 - (27%)
• Similarity: 240/567 - (42%)
• Gaps: 86/567 - (15%)

  Fly    14 MPSVQSLSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAK 78
            |.:..:.::||....|:|:.|.|...:..   |..||||..||.||.|..|...|.:..|.:|:|
Human     1 MEATGTWALLLALALLLLLTLALSGTRAR---GHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSK 62

  Fly    79 RYGGIFELKMGR-VPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHA 140
            :||.:|.:.:|. .|.|||.....||:..  :.:..:||..:.:..|...|.|:..:..:.||..
Human    63 KYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127

  Fly   141 RRETIDWLKALGMTRRPGELRARLERRIARGVDEC-VRLFD-TEAKKSCASEVNPLPALHHSLGN 203
            |:.|:..|:.|||.:|.||...:.|.|       | |..|. ||.:     ..:|...|..:..|
Human   128 RKFTMLALRDLGMGKREGEELIQAEAR-------CLVETFQGTEGR-----PFDPSLLLAQATSN 180

  Fly   204 IINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG----VVNFLPW-LRHLPANVRNIRFLLEG 263
            ::..|:||:.:..:|.::..:.|  ..|..|:|||.    ......| ||.||...:.   ||..
Human   181 VVCSLLFGLRFSYEDKEFQAVVR--AAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQ---LLHH 240

  Fly   264 KAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEE 328
            .:...|...|.|:                                        |.|...|.....
Human   241 VSTLAAFTVRQVQ----------------------------------------QHQGNLDASGPA 265

  Fly   329 SDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQ 393
            .|..|.:    :|:.....::..::....:.|..::..|| ||..|...|:.:.||.|.:....|
Human   266 RDLVDAF----LLKMAQEEQNPGTEFTNKNMLMTVIYLLF-AGTMTVSTTVGYTLLLLMKYPHVQ 325

  Fly   394 RRLHELL---LPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGS 455
            :.:.|.|   |..|.:|:|.:...|.|..|.:.|..|:.::||:|||...........|.:..|:
Human   326 KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGT 390

  Fly   456 MIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTG 520
            .:.....:|..||..|..||||.|:|||.|||.::....|:|||.|.|:|.||.:|:..|.||..
Human   391 EVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFT 455

  Fly   521 RILRRFHLELPSGTEVDMAGESGITLTPTPHMLRFTKLPAVEMRHAP 567
            .||:.|.||.|...:.       ::|.||...| |...||.:::..|
Human   456 TILQAFSLESPCPPDT-------LSLKPTVSGL-FNIPPAFQLQVRP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	143/518 (28%)
CYP2S1	NP_085125.1	p450	49..488	CDD:365848	135/508 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910