Protein Alignment phtm and Cyp2d5

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_775426.1
• Gene: Cyp2d5 / 286963
• RGDID: 628630
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 568
• Identity: 149/568 - (26%)
• Similarity: 230/568 - (40%)
• Gaps: 119/568 - (20%)

  Fly    24 LVPGALVLVILYLCERQCNDLM-------GAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYG 81
            |.|.|:..||..|..    |||       ...||||...|.||.|..:|......|:.||..|||
  Rat     9 LWPMAIFTVIFILLV----DLMHRHQRWTSRYPPGPVPWPVLGNLLQVDPSNMPYSMYKLQHRYG 69

  Fly    82 GIFELKMGRVPTVVLSDAALVRDFFRRDVMTGRAPLYLTHG----------IMGGFGIICAQEDI 136
            .:|.|:||..|.|:::....|::            :.:|||          |....|:....:.:
  Rat    70 DVFSLQMGWKPMVIVNRLKAVQE------------VLVTHGEDTADRPPVPIFKCLGVKPRSQGV 122

  Fly   137 --------WRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNP 193
                    ||..||.::..|:..||.::      .||..:.:........|..:..:|    :||
  Rat   123 VFASYGPEWREQRRFSVSTLRTFGMGKK------SLEEWVTKEAGHLCDAFTAQNGRS----INP 177

  Fly   194 LPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG----VVNFLPWLRHLPANV 254
            ...|:.:|.|:|..|:|...::.:||..:.:..|.||  .||.|||    |:|..|.|..:|
  Rat   178 KAMLNKALCNVIASLIFARRFEYEDPYLIRMLTLVEE--SLIEVSGFIPEVLNTFPALLRIP--- 237

  Fly   255 RNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQ 319
                    |.|                    .|||   |.||.....|:..........||:|
  Rat   238 --------GLA--------------------DKVF---QGQKTFMAFLDNLLAENRTTWDPAQ-- 269

  Fly   320 SEADEDDEESDEEDTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLR 380
                            .|..:.:.|||    .:......:.|:.||.::.|||.||:.|:..||.
  Rat   270 ----------------PPRNLTDAFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLT 318

  Fly   381 W----FLLYLAREQRCQRRLHELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCK 441
            |    .:||...::|.|:.:.|::..: ..|.:.:...:.|..|.|.|..|...:.||.:|....
  Rat   319 WALLLMILYPDVQRRVQQEIDEVIGQV-RCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITS 382

  Fly   442 ENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCP 506
            .:..|.|:.|..|:.::.:..::..|...:.:|..|.||.||.|.|.:.....|:|||:|.|.|.
  Rat   383 CDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACL 447

  Fly   507 GEEMARMILTLFTGRILRRFHLELPSG-TEVDMAGESGITLTPTPHML 553
            ||.:|||.|.||...:|:.|...:|:| ......|...|::.|.|:.|
  Rat   448 GEPLARMELFLFFTCLLQHFSFSVPAGQPRPSTLGNFAISVAPLPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	125/502 (25%)
Cyp2d5	NP_775426.1	CYP2D	68..495	CDD:410756	126/503 (25%)