DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phm and Cyp2b3

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_775416.1	Gene:	Cyp2b3 / 286953	RGDID:	628627	Length:	491	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	140/546 - (25%)
Similarity:	220/546 - (40%)	Gaps:	94/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFE 85
            |:||:...|:..:|:|...... :.|..||||..||.||.|..:|.....||..:|.:::|.:|.
  Rat     4 SVLLLLAVLLSFLLFLVRGHAK-VHGHLPPGPRPLPLLGNLLQMDRGGFRKSFIQLQEKHGDVFT 67

  Fly    86 LKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDWL 148
            :..|..|.|:|.....:|:..  ..:..:||..:.:...||..:|:....|:.|:..||..:..:
  Rat    68 VYFGPRPVVMLCGTQTIREALVDHAEAFSGRGIIAVLQPIMQEYGVSFVNEERWKILRRLFVATM 132

  Fly   149 KALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGIT 213
            :..|:.::..|.:.:.|.:       |:   ..|.|......::|........||||..:|||..
  Rat   133 RDFGIGKQSVEDQIKEEAK-------CL---VEELKNHQGVSLDPTFLFQCVTGNIICSIVFGER 187

  Fly   214 YKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEAC 278
            :...|..:|.|..|......||.                                :...::.|..
  Rat   188 FDYRDRQFLRLLDLLYRTFSLIS--------------------------------SFSSQMFEVY 220

  Fly   279 GQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEH 343
            ...||....|.:|:  .|.|:..|:        ..|.|.|...|..|..        .|...::.
  Rat   221 SDFLKYFPGVHREI--YKNLKEVLD--------YIDHSVENHRATLDPN--------APRDFIDT 267

  Fly   344 FLAVRDTDSQLYCD-DQLRHL-----------LADLFGAGVDTSLATLRW-FLLYLAREQRCQRR 395
            ||        |:.: ::|.|.           :..||.||.:::..||.: |||.|......::.
  Rat   268 FL--------LHMEKEKLNHYTEFHHWNLMISVLFLFLAGTESTSNTLCYGFLLMLKYPHVAEKV 324

  Fly   396 LHELLLPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGC---KENFVVGDYFIKGGS 455
            ..|:...:|..  |||::...:.|..|.|.|..|...|.|:|:|  |   |:....|....|...
  Rat   325 QKEIDQVIGSQRVPTLDDRSKMPYTEAVIHEIQRFSDVSPMGLP--CRITKDTLFRGYLLPKNTE 387

  Fly   456 MIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTG 520
            :......|:| ||..|.:|:.|.||.||.|:||.:....|:|||.|.|||.||.:||..|.||..
  Rat   388 VYFILSSALH-DPQYFEQPDTFNPEHFLDANGALKKCEAFMPFSIGKRMCLGEGIARSELFLFFT 451

  Fly   521 RILRRFHLELP-SGTEVDMA-GESGI 544
            .||:.:.:..| ....:||. .|||:
  Rat   452 TILQNYSVSSPVDPNTIDMTPKESGL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	133/518 (26%)
Cyp2b3	NP_775416.1	p450	42..488	CDD:278495	125/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000