Protein Alignment phtm and Cyp2e1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_113731.2
• Gene: Cyp2e1 / 25086
• RGDID: 2475
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 557
• Identity: 146/557 - (26%)
• Similarity: 253/557 - (45%)
• Gaps: 89/557 - (15%)

  Fly    16 SVQSLSILLVPGALVLVILYLCERQCN--DLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAK 78
            :|..::|.|:.....|:::.:.::..|  :|    ||||:.||.||.:..||.:...||..||||
  Rat     2 AVLGITIALLVWVATLLVISIWKQIYNSWNL----PPGPFPLPILGNIFQLDLKDIPKSFTKLAK 62

  Fly    79 RYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRA--PLYLTHGIMGGFGIICAQEDIWRH 139
            |:|.:|.|.:|....|||.....|::..  .::..:||.  |::..:   ...|||......|:.
  Rat    63 RFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEY---KNKGIIFNNGPTWKD 124

  Fly   140 ARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNI 204
            .||.::..|:..||.::..|  ||::|.        .:....|.||:.....:|...:..:..|:
  Rat   125 VRRFSLSILRDWGMGKQGNE--ARIQRE--------AQFLVEELKKTKGQPFDPTFLIGCAPCNV 179

  Fly   205 INDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVV---NFLPWLRHLPANVRNIRFLLEGKAK 266
            |.|::|...:..:|...|.|..|..|...|:....:.   ||..:||:||.:.|
  Rat   180 IADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHR----------- 233

  Fly   267 THAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDE 331
                                |:.|.:.|.|:...:..||.| ||.:.:.:::.:
  Rat   234 --------------------KIMKNVSEIKQYTLEKAKEHL-QSLDINCARDVT----------- 266

  Fly   332 EDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRL 396
                  :|:|......:.:...:|..:.:...|||||.||.:|:..|||:.||.|.:....:.:|
  Rat   267 ------DCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325

  Fly   397 HELL-LPLGPS--PTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIV 458
            ||.: ..:|||  |.:.:...:.|:.|.:.|..|..::||..:||....:.|...|.|..|::::
  Rat   326 HEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVI 390

  Fly   459 CSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRIL 523
            .:..::..|...||:||:|:||.||..:|.::....|..||:|.|:|.||.:|||.|.|....||
  Rat   391 PTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAIL 455

  Fly   524 RRFHLE-LPSGTEVDMAGESGITLTPTPHMLRFTKLP 559
            :.|:|: |....::|:          :|..:.|..:|
  Rat   456 QHFNLKSLVDPKDIDL----------SPVTVGFGSIP 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	121/482 (25%)
Cyp2e1	NP_113731.2	CYP2C-like	64..487	CDD:410758	123/491 (25%)