DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2d2

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_036862.2	Gene:	Cyp2d2 / 25053	RGDID:	2471	Length:	500	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	142/524 - (27%)
Similarity:	226/524 - (43%)	Gaps:	84/524 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDF---FRRDV 110
            ||||..||.||.|..:|......||.||..|||.:|.|::...|.||::....||:.   :..|
  Rat    37 PPGPVPLPGLGNLLQVDFENMPYSLYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGED- 100

  Fly   111 MTGRAPLYLTHGIMGGFG------IICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIA 169
             |...||...:..: |:|      ::......||..||.::..|:..|:.::      .||:.:
  Rat   101 -TADRPLLPIYNHL-GYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGVGKK------SLEQWV- 156

  Fly   170 RGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDW-LYLQRLQEEGVK 233
              .:|...|.||.||:: ....||...|..::.|:|..||:...::.:||.: ..|:.|:|...:
  Rat   157 --TEEAGHLCDTFAKEA-EHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGE 218

  Fly   234 LIG-VSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKR 297
            ..| ::.|:|.:|.|..:|.        |.|                       |||.:|.....
  Rat   219 DTGFMAEVLNAIPILLQIPG--------LPG-----------------------KVFPKLNSFIA 252

  Fly   298 LQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLA----VRDTDSQLYCDD 358
            |   ::|..:...|..||:|                  .|..:.:.|||    .:......:.|:
  Rat   253 L---VDKMLIEHKKSWDPAQ------------------PPRDMTDAFLAEMQKAKGNPESSFNDE 296

  Fly   359 QLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHELL---LPLGPSPTLEELEPLAYLRA 420
            .||.::.|||.||:.|:..||.|.||.:......|||:||.:   :.....|.:.:...:.:..|
  Rat   297 NLRLVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNA 361

  Fly   421 CISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTA 485
            .|.|..|...:||..|||....:.....:.|..|:.::.:..::..|...:.:|..|.||.||.|
  Rat   362 VIHEVQRFADIVPTNIPHMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDA 426

  Fly   486 DGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSG-TEVDMAGESGITLTPT 549
            .|.:.....|:|||:|.|.|.||.:|||.|.||...:|:||...:.:| ......|...:.:||.
  Rat   427 QGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQ 491

  Fly   550 PHML 553
            |:.|
  Rat   492 PYQL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	142/524 (27%)
Cyp2d2	NP_036862.2	CYP2D	68..495	CDD:410756	126/491 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000