Protein Alignment phtm and Cyp2c12

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_113760.2
• Gene: Cyp2c12 / 25011
• RGDID: 2470
• Length: 490
• Species: Rattus norvegicus
• Alignment Length: 552
• Identity: 147/552 - (26%)
• Similarity: 230/552 - (41%)
• Gaps: 98/552 - (17%)

  Fly    22 ILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIFEL 86
            ::||.....|::|||......  .|..||||..||..|....:|.:...:|:...:|.||.:|.|
  Rat     5 VVLVLSLSFLLLLYLWRPSPG--RGKLPPGPTPLPIFGNFLQIDMKDIRQSISNFSKTYGPVFTL 67

  Fly    87 KMGRVPTVVLSDAALVR----DFFRRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDW 147
            ..|..|||||.....|:    |:.......||.|::  .....|.||..::.::||..|..|::.
  Rat    68 YFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVF--EKATKGLGISFSRGNVWRATRHFTVNT 130

  Fly   148 LKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGI 212
            |::|||.:|..|::          |.|.......|.||:..|..:|...:..:..|:|..::|..
  Rat   131 LRSLGMGKRTIEIK----------VQEEAEWLVMELKKTKGSPCDPKFIIGCAPCNVICSIIFQN 185

  Fly   213 TYKRDDPDWLYLQRLQEEGVKLIGVSG--VVNFLPWLRHLPANVRNIRFLLE---GKAKTHAIYD 272
            .:...|.|:|.|.....|.:|::....  |.|..|             .||:   |..|||:.:.
  Rat   186 RFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNAFP-------------ILLDYCPGNHKTHSKHF 237

  Fly   273 RIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEESDEEDTYEP 337
            ..:         |..:.|:::|.                               |||  .|...|
  Rat   238 AAI---------KSYLLKKIKEH-------------------------------EES--LDVSNP 260

  Fly   338 ECILEHFLAVR---DTDSQL-YCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQRRLHE 398
            ...:::||..|   :.:.|: |..:.|..|:.:||..|.:||..|||:.||.|.:......::.|
  Rat   261 RDFIDYFLIQRCQENGNQQMNYTQEHLAILVTNLFIGGTETSSLTLRFALLLLMKYPHITDKVQE 325

  Fly   399 LLLPLGP------SPTLEELEPLAYLRACISETMRIRSVVPLGIPH--GCKENFVVGDYFIKGGS 455
               .:|.      ||.:.:...:.|..|.|.|..|...:.|.|:.|  .|...|  .||||..|:
  Rat   326 ---EIGQVIGRHRSPCMLDRIHMPYTNAMIHEVQRYIDLAPNGLLHEVTCDTKF--RDYFIPKGT 385

  Fly   456 MIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTG 520
            .::.|..::..|...||.||.|.|..||..:|.::....|:|||:|.|.|.||.:|.|.|.||..
  Rat   386 AVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFMPFSAGKRKCVGEGLASMELFLFLT 450

  Fly   521 RILRRFHLEL---PSGTEVDMAGESGITLTPT 549
            .||:.|.|:.   |...:::.......::.||
  Rat   451 TILQNFKLKSLSDPKDIDINSIRSEFSSIPPT 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	129/493 (26%)
Cyp2c12	NP_113760.2	CYP2C-like	61..485	CDD:410758	130/494 (26%)