DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2a1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_036824.1	Gene:	Cyp2a1 / 24894	RGDID:	2463	Length:	492	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	129/561 - (22%)
Similarity:	244/561 - (43%)	Gaps:	89/561 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSILLVPGALVLVILYLCERQCNDLMGAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYGGIF 84
            |.::::....|::::.|.:::   :.|..||||..|||:|....|:.:..:.|:.:|::|||.:|
  Rat     7 LLVVILASLSVMLLVSLWQQK---IRGRLPPGPTPLPFIGNYLQLNTKDVYSSITQLSERYGPVF 68

  Fly    85 ELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFGIICAQEDIWRHARRETIDW 147
            .:.:|....|||.....|::..  :.:..:||......:.:..|:|:..:..:..:..||.:|..
  Rat    69 TIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGEQATYNTLFKGYGVAFSSGERAKQLRRLSIAT 133

  Fly   148 LKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHSLGNIINDLVFGI 212
            |:..|:.:|      .:|.||.......:::.    :.:|.:.::|...|..::.|:|:.:|||.
  Rat   134 LRDFGVGKR------GVEERILEEAGYLIKML----QGTCGAPIDPTIYLSKTVSNVISSIVFGE 188

  Fly   213 TYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWLRHLPANVRNIRFLLEGKAKTHAIYDRIVEA 277
            .:..:|.::|          .|:.:.|.:|               ||   ..:.|..:||.....
  Rat   189 RFDYEDTEFL----------SLLQMMGQMN---------------RF---AASPTGQLYDMFHSV 225

  Fly   278 CGQRLKEKQKVFKELQEQKRLQRQLEK---EQLRQSKEA-DPSQEQSEADEDDEESDEEDTYEPE 338
            .......:|::.|..|       :||.   |::||:... ||:                   .|.
  Rat   226 MKYLPGPQQQIIKVTQ-------KLEDFMIEKVRQNHSTLDPN-------------------SPR 264

  Fly   339 CILEHFLAVRDTDSQLYCDDQLRHLL---ADLFGAGVDTSLATLRWFLLYLAREQRCQRRLH--- 397
            ..::.||.....:.....:..:::|:   ..||.||.:|..:|||:..|.|.:....:.::|
  Rat   265 NFIDSFLIRMQEEKNGNSEFHMKNLVMTTLSLFFAGSETVSSTLRYGFLLLMKHPDVEAKVHEEI 329

  Fly   398 ELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSMIVCSEW 462
            |.::.....|..|:...:.|.:|.|:|..|..::.|||||....:|.....:|:...:.:.....
  Rat   330 EQVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPKATDVFPILG 394

  Fly   463 AIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGRILRRFH 527
            ::..||..||.|::|.|:.||...|..:....|:|||:|.|.|.|:.:|:|.|.|....||:.|.
  Rat   395 SLMTDPKFFPSPKDFDPQNFLDDKGQLKKNAAFLPFSTGKRFCLGDGLAKMELFLLLTTILQNFR 459

  Fly   528 LELPSGTEVDMAGESGITLTPTPHMLRFTK-LPAVEMRHAP 567
            .:.|...|         .:..:|..|.||: :|...|...|
  Rat   460 FKFPMKLE---------DINESPKPLGFTRIIPKYTMSFMP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	120/517 (23%)
Cyp2a1	NP_036824.1	p450	33..489	CDD:278495	124/528 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000