Protein Alignment phtm and Cyp2r1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_796356.2
• Gene: Cyp2r1 / 244209
• MGIID: 2449771
• Length: 501
• Species: Mus musculus
• Alignment Length: 552
• Identity: 149/552 - (26%)
• Similarity: 247/552 - (44%)
• Gaps: 96/552 - (17%)

  Fly    27 GALVLVILYLCERQCNDLM-----GAPPPGPWGLPFLGYL--PFLDARAPHKSLQKLAKRYGGIF 84
            |||:|::..|..||   |:     ...||||..|||:|.:  ..|.|..||..::|.::.||.||
Mouse    16 GALLLLLFVLVVRQ---LLRQRRPAGFPPGPPRLPFVGNICSLALSADLPHVYMRKQSRVYGEIF 77

  Fly    85 ELKMGRVPTVVLSDAALVRD--FFRRDVMTGR--APLYLTHGIMGGF-------GIICAQEDIWR 138
            .|.:|.:.||||:...:|::  ..:.::...|  .||::....|||.       |        |.
Mouse    78 SLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--------WI 134

  Fly   139 HARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDT-EAKKSCASEVNPLPALHHSLG 202
            ..||..::.....|..::..|         ::.::|...|.|. |..|....::..|  :.:::.
Mouse   135 DHRRLAVNSFHYFGSGQKSFE---------SKILEETWSLIDAIETYKGGPFDLKQL--ITNAVS 188

  Fly   203 NIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGV--VNFLPWLRHLPANVRNIRFLLEGKA 265
            ||.|.::||..:..:|.|:.::..|..|.|:|...:.|  .|..||:..||.          ||
Mouse   189 NITNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNAFPWIGILPF----------GK- 242

  Fly   266 KTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDE-ES 329
              |           |||.....|..:.     |.|.:||..:.:..........:..||.|: ::
Mouse   243 --H-----------QRLFRNADVVYDF-----LSRLIEKAAVNRKPHLPHHFVDAYLDEMDQGQN 289

  Fly   330 DEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQR 394
            |...|:..|                    .|...:.:|..||.:|:...|||.:|::|.....|.
Mouse   290 DPLSTFSKE--------------------NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQG 334

  Fly   395 RLH---ELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSM 456
            ::|   :|::.....|:.|....:.|..|.:.|.:|..::|||||.|...|:.||..|.|..|:.
Mouse   335 QVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTT 399

  Fly   457 IVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGR 521
            ::.:.:::|.|...:.:|:.|.|||||.::|.:......||||.|.|.|.||::|||.:.||...
Mouse   400 VITNLYSVHFDEKYWKDPDMFYPERFLDSNGYFTKKEALIPFSLGRRHCLGEQLARMEMFLFFTS 464

  Fly   522 ILRRFHLELPSGTEVDMAGESGITLTPTPHML 553
            :|::|||..|.....::....|:||.|.|:::
Mouse   465 LLQQFHLHFPHELVPNLKPRLGMTLQPQPYLI 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	127/489 (26%)
Cyp2r1	NP_796356.2	cytochrome_P450	62..497	CDD:477761	131/503 (26%)