DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2r1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_796356.2	Gene:	Cyp2r1 / 244209	MGIID:	2449771	Length:	501	Species:	Mus musculus

Alignment Length:	552	Identity:	149/552 - (26%)
Similarity:	247/552 - (44%)	Gaps:	96/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GALVLVILYLCERQCNDLM-----GAPPPGPWGLPFLGYL--PFLDARAPHKSLQKLAKRYGGIF 84
            |||:|::..|..||   |:     ...||||..|||:|.:  ..|.|..||..::|.::.||.||
Mouse    16 GALLLLLFVLVVRQ---LLRQRRPAGFPPGPPRLPFVGNICSLALSADLPHVYMRKQSRVYGEIF 77

  Fly    85 ELKMGRVPTVVLSDAALVRD--FFRRDVMTGR--APLYLTHGIMGGF-------GIICAQEDIWR 138
            .|.:|.:.||||:...:|::  ..:.::...|  .||::....|||.       |        |.
Mouse    78 SLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--------WI 134

  Fly   139 HARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDT-EAKKSCASEVNPLPALHHSLG 202
            ..||..::.....|..::..|         ::.::|...|.|. |..|....::..|  :.:::.
Mouse   135 DHRRLAVNSFHYFGSGQKSFE---------SKILEETWSLIDAIETYKGGPFDLKQL--ITNAVS 188

  Fly   203 NIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGV--VNFLPWLRHLPANVRNIRFLLEGKA 265
            ||.|.::||..:..:|.|:.::..|..|.|:|...:.|  .|..||:..||.          ||
Mouse   189 NITNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNAFPWIGILPF----------GK- 242

  Fly   266 KTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDE-ES 329
              |           |||.....|..:.     |.|.:||..:.:..........:..||.|: ::
Mouse   243 --H-----------QRLFRNADVVYDF-----LSRLIEKAAVNRKPHLPHHFVDAYLDEMDQGQN 289

  Fly   330 DEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQRCQR 394
            |...|:..|                    .|...:.:|..||.:|:...|||.:|::|.....|.
Mouse   290 DPLSTFSKE--------------------NLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQG 334

  Fly   395 RLH---ELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYFIKGGSM 456
            ::|   :|::.....|:.|....:.|..|.:.|.:|..::|||||.|...|:.||..|.|..|:.
Mouse   335 QVHKEIDLIVGHNRRPSWEYKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTT 399

  Fly   457 IVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMILTLFTGR 521
            ::.:.:::|.|...:.:|:.|.|||||.::|.:......||||.|.|.|.||::|||.:.||...
Mouse   400 VITNLYSVHFDEKYWKDPDMFYPERFLDSNGYFTKKEALIPFSLGRRHCLGEQLARMEMFLFFTS 464

  Fly   522 ILRRFHLELPSGTEVDMAGESGITLTPTPHML 553
            :|::|||..|.....::....|:||.|.|:::
Mouse   465 LLQQFHLHFPHELVPNLKPRLGMTLQPQPYLI 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	141/525 (27%)
Cyp2r1	NP_796356.2	p450	40..497	CDD:278495	141/525 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24300
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010