Protein Alignment phtm and Cyp2d3

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_775116.1
• Gene: Cyp2d3 / 24303
• RGDID: 2472
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 144/559 - (25%)
• Similarity: 233/559 - (41%)
• Gaps: 101/559 - (18%)

  Fly    24 LVPGALVLVILYLCERQCNDLM-------GAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYG 81
            |.|.|:..||..|..    |||       ...||||...|.||.|..:|......|:.||..|||
  Rat     9 LWPMAIFTVIFILLV----DLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLCNMPYSMYKLQNRYG 69

  Fly    82 GIFELKMGRVPTVVLSDAALVRDFFRRDVMTG-----RAPLYLTHGIMGGFG------IICAQED 135
            .:|.|:||..|.||::....|::..   |..|     |..:.:...|  |:|      ::.....
  Rat    70 DVFSLQMGWKPVVVINGLKAVQELL---VTCGEDTADRPEMPIFQHI--GYGHKAKGVVLAPYGP 129

  Fly   136 IWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVNPLPALHHS 200
            .||..||.::..|:..|:.::      .||:.:   .||...|.|....:: ...::|...|:.:
  Rat   130 EWREQRRFSVSTLRNFGVGKK------SLEQWV---TDEASHLCDALTAEA-GRPLDPYTLLNKA 184

  Fly   201 LGNIINDLVFGITYKRDDPDWLYLQRLQEEGV-KLIGV-SGVVNFLPWLRHLPANVRNIRFLLEG 263
            :.|:|..|::...:...|||::.:.::.:|.: :..|: ..|:|..|.|..:|           |
  Rat   185 VCNVIASLIYARRFDYGDPDFIKVLKILKESMGEQTGLFPEVLNMFPVLLRIP-----------G 238

  Fly   264 KAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEADEDDEE 328
            .|                    .|||   ..||.....::.......|..||.|
  Rat   239 LA--------------------DKVF---PGQKTFLTMVDNLVTEHKKTWDPDQ----------- 269

  Fly   329 SDEEDTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAR- 388
                   .|..:.:.|||    .:......:.|..||.::.||||||:.|:..||.|.||.:..
  Rat   270 -------PPRDLTDAFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILH 327

  Fly   389 ---EQRCQRRLHELLLPLGPSPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFVVGDYF 450
               :.|.|:.:.|::..: ..|.:.:...:.:..|.|.|..|...:||:.:||....:..|..:.
  Rat   328 PDVQCRVQQEIDEVIGQV-RHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFL 391

  Fly   451 IKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEMARMIL 515
            |..|:.::.:..::..|...:.:|..|.||.||.|.|.:.....|:|||:|.|.|.||.:|||.|
  Rat   392 IPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMEL 456

  Fly   516 TLFTGRILRRFHLELPSG-TEVDMAGESGITLTPTPHML 553
            .||...:|:||...:|:| ......|.....|:|:|:.|
  Rat   457 FLFFTCLLQRFSFSVPTGQPRPSDYGVFAFLLSPSPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	120/493 (24%)
Cyp2d3	NP_775116.1	CYP2D	68..495	CDD:410756	121/494 (24%)