Protein Alignment phtm and Cyp21a1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_476442.2
• Gene: Cyp21a1 / 24298
• RGDID: 2461
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 597
• Identity: 144/597 - (24%)
• Similarity: 236/597 - (39%)
• Gaps: 157/597 - (26%)

  Fly    23 LLVPGALVLVILYLCERQCNDLMGA--------------PPPGPWGLPFLGYLPFLDARAPHKSL 73
            :|:||.|:|::|.|       |.|.              ||..|      |:|.||....| ..|
  Rat     1 MLLPGLLLLLLLLL-------LAGTRWLWGQWKLWKLRLPPLAP------GFLHFLQPNLP-VYL 51

  Fly    74 QKLAKRYGGIFELKMGRVPTVVLS-----DAALVR---DFF-RRDVMTGRAPLYLTHGIMGGFGI 129
            ..||::.|.|:.:::|....|||:     :.||::   ||. |..::.|:....|:   ||.:.:
  Rat    52 FGLAQKLGPIYRIRLGLQDVVVLNSNKTIEEALIQKWVDFAGRPQILDGKMNFDLS---MGDYSL 113

  Fly   130 ICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDE-CVRLFDTEAKKSCASEVNP 193
                  .|: |.::.......|||       |..:|..:.:...| |.|:         .::...
  Rat   114 ------TWK-AHKKLSRSALVLGM-------RDSMEPLVEQLTQEFCERM---------RAQAGA 155

  Fly   194 LPALHHSLG----NIINDLVFGITYKRDDPDWL---------YLQRLQEEGVKLIGVSGVVNFLP 245
            ..|:|....    :||:.|.||   .:.|...|         .|:......|:::.:      :|
  Rat   156 SVAIHKEFSLLTCSIISCLTFG---DKQDSTLLNATHSCVRDLLKAWNHWSVQILDI------IP 211

  Fly   246 WLRHLP-ANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQ 309
            :||..| ..:..::...|.:       |.||                :||.||     .|:.|..
  Rat   212 FLRFFPNPGLWKLKQFQESR-------DHIV----------------MQELKR-----HKDSLVA 248

  Fly   310 SKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHL---LADLFGAG 371
            .:..|......:..|     .:.|..:|..:.|                  ||:   :.|||..|
  Rat   249 GQWKDMIDYMLQGVE-----KQRDARDPGQLHE------------------RHVHMSVVDLFVGG 290

  Fly   372 VDTSLATLRWFLLYLAREQRCQRRLHELL-LPLGPSPTL--EELEPLAYLRACISETMRIRSVVP 433
            .:|:.|||.|.:.:|......|:||.|.| |.|.||..|  :....|..|.|.|:|.:|:|.|||
  Rat   291 TETTAATLSWAVAFLLHHPEIQKRLQEELDLKLAPSSQLLYKNRMQLPLLMATIAEVLRLRPVVP 355

  Fly   434 LGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPF 498
            :.:||...:...:..|.|...::|:.:....::|.:.:..|.:|.|:|||.:..:    |:...|
  Rat   356 MALPHRATKASSISGYDIPKDTIIIPNIQGANLDEMVWELPSKFWPDRFLESGKS----PRIPTF 416

  Fly   499 SSGYRMCPGEEMARMILTLFTGRILRRFH-LELPSGTEVDMAGESGITLTPTPHMLRFTKLPAVE 562
            ..|.|:|.||.:||:.|.:...|:|:.|. |..|.||..        :|.|.|:......:|..:
  Rat   417 GCGARVCLGEPLARLELFVVLARLLQTFTLLPPPDGTLP--------SLQPLPYTGINLLIPPFQ 473

  Fly   563 MRHAPDGAVVQD 574
            :|..|.....||
  Rat   474 VRLQPRNLAPQD 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	119/502 (24%)
Cyp21a1	NP_476442.2	CYP21	58..477	CDD:410767	121/516 (23%)