Protein Alignment phtm and Cyp1a1

DIOPT Version :10

• Sequence 1: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_036672.3
• Gene: Cyp1a1 / 24296
• RGDID: 2458
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 569
• Identity: 156/569 - (27%)
• Similarity: 242/569 - (42%)
• Gaps: 103/569 - (18%)

  Fly    14 MPSVQSLSILLVPGALVLVILYLCERQCNDLMG---------------APPPGPWGLPFLGYLPF 63
            ||||...........|:|.:...|       :|               ..|||||||||:|::..
  Rat     1 MPSVYGFPAFTSATELLLAVTTFC-------LGFWVVRVTRTWVPKGLKSPPGPWGLPFIGHVLT 58

  Fly    64 LDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLS-----DAALVRDFFRRDVMTGRAPLYLTHGI 123
            | .:.||.||.||:::||.:.::::|..|.||||     ..|||:   :.|...||..||....|
  Rat    59 L-GKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVK---QGDDFKGRPDLYSFTLI 119

  Fly   124 MGGFGIICAQED--IWRHARRETIDWLKALGMTRRPG-ELRARLERRIARGVDECVRLFDTEAKK 185
            ..|..:....:.  :|...||...:.||:..:...|. .....||..:::..:..:..|     :
  Rat   120 ANGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSCYLEEHVSKEAEYLISKF-----Q 179

  Fly   186 SCASEV---NPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGVVNFLPWL 247
            ...:||   :|...|..|:.|:|..:.||..|..||.:.|.:..|..|..::.|.....:|:|.|
  Rat   180 KLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSGYPADFIPIL 244

  Fly   248 RHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQ--KRLQRQLEKEQLRQS 310
            |:||                    :..::|    .|:..|.|....::  |...|..||..:|..
  Rat   245 RYLP--------------------NSSLDA----FKDLNKKFYSFMKKLIKEHYRTFEKGHIRDI 285

  Fly   311 KEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVR---DTDSQLYCDDQLRHLLADLFGAGV 372
            .::                          ::||....|   :.:.|| .||::..::.||||||.
  Rat   286 TDS--------------------------LIEHCQDRRLDENANVQL-SDDKVITIVFDLFGAGF 323

  Fly   373 DTSLATLRWFLLYLAREQRCQRRLHELL---LPLGPSPTLEELEPLAYLRACISETMRIRSVVPL 434
            ||....:.|.|:||....|.||::.|.|   :.....|.|.:...|.||.|.|.||.|..|.||.
  Rat   324 DTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPF 388

  Fly   435 GIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAY--QAPPQFIP 497
            .|||....:..:..::|..|..:..::|.::.|...:.:|.|||||||||:.|..  ....:.|.
  Rat   389 TIPHSTIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKHLSEKVIL 453

  Fly   498 FSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGESGITL 546
            |..|.|.|.||.:.|:.:.||...:|::....:..|.:|||....|:||
  Rat   454 FGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLTL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	130/487 (27%)
Cyp1a1	NP_036672.3	Mitochondrial targeting signal. /evidence=ECO:0000269|PubMed:19401463, ECO:0000269|PubMed:9348277	33..44		0/10 (0%)
		CYP1A	74..509	CDD:410769	131/488 (27%)