DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phm and Cyp2ab1

DIOPT Version :9

Sequence 1:	NP_001285414.1	Gene:	phm / 32857	FlyBaseID:	FBgn0004959	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_017172441.1	Gene:	Cyp2ab1 / 224044	MGIID:	3644957	Length:	459	Species:	Mus musculus

Alignment Length:	513	Identity:	140/513 - (27%)
Similarity:	231/513 - (45%)	Gaps:	95/513 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LGYLPFLDARAPHKSLQKLAKRYGGIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLT 120
            :|||.     :|     :||:.:|.:|.:.:|..|.||||....|::..  ..:..:||......
Mouse    11 MGYLV-----SP-----QLAQTHGSVFTVWLGSTPIVVLSGFRAVKEALVSNSEQFSGRPLTPFF 65

  Fly   121 HGIMGGFGIICAQEDIWRHARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKK 185
            ..:.|..|:||:....||..||..:..|:.||:.::  .|..:|:...|    |..::|..|..:
Mouse    66 RDLFGEKGVICSNGLTWRQQRRFCLTTLRELGLGKQ--ALEVQLQHEAA----ELAKVFLQEEGR 124

  Fly   186 SCASEVNPLPALHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSGV----VNFLPW 246
            :    .:|...:..|...:|..||||..:..::|  ::|:.:|...:.|...|.:    .:..||
Mouse   125 A----FDPQIPIIRSTTRVIGTLVFGHHFLSEEP--IFLELIQAINLGLAFASTIWRRLYDMFPW 183

  Fly   247 -LRHLPANVRNIRFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKR--LQRQLEKEQLR 308
             ||||..                               ..||:| :..|..|  ::.::.:.:||
Mouse   184 ALRHLSG-------------------------------PHQKIF-QYHEAVRGFIRHEIIRHKLR 216

  Fly   309 QSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQLYCDDQLRHLLADLFGAGVD 373
                      .:||.:|          ...|.|.......|.....:.::.|..::.|||..|.|
Mouse   217 ----------TAEAPKD----------FINCYLSQITKAIDDPVSTFSEENLIQVVIDLFLGGTD 261

  Fly   374 TSLATLRWFLLYL----AREQRCQRRLHELLLPLGPSPTL--EELEPLAYLRACISETMRIRSVV 432
            |:..||.|.|:||    |.::|.|:.|.|:   ||.:.|:  |:.|.|.|.||.:.|..|:.|||
Mouse   262 TTATTLHWALIYLVHHRAIQERVQQELDEM---LGAAQTICYEDRERLPYTRAVLHEVQRLSSVV 323

  Fly   433 PLGIPHGCKENFVVGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIP 497
            .:|....|..:..:..|::..|::|:.:..::..||..:..|.:|.|..||..||.:.|...|:|
Mouse   324 AVGAVRQCVTSTWMHGYYVPKGTIILPNLASVLYDPECWESPHQFNPGHFLDKDGNFVANEAFLP 388

  Fly   498 FSSGYRMCPGEEMARMILTLFTGRILRRFHLELPSGTEVDMAGE--SGITLTPTPHML 553
            ||:|:|:||||::|||.|.|....:||.|..:||.|:: |:..|  .|.||.|.|..:
Mouse   389 FSAGHRVCPGEQLARMELFLMFATLLRTFQFQLPEGSQ-DLGLEYVFGGTLQPQPQKI 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phm	NP_001285414.1	p450	49..555	CDD:278495	140/513 (27%)
Cyp2ab1	XP_017172441.1	p450	18..446	CDD:365848	136/496 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4289
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950